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An enzyme that helps convert glucose into energy. It is found throughout the body but is primarily found in high levels in muscle tissue. It is elevated in the bloodstream when a patient has muscle or liver damage or disease.

High levels are found in progressive Duchenne muscular dystrophy (MD). Elevations occur in carriers of MD, in limb-girdle dystrophy and other dystrophies, in dermatomyositis, polymyositis, and trichinosis, but not in neurogenic atrophies (eg, multiple sclerosis or in myasthenia gravis).