LabCorp Test

Chloride Urine Test, 24-Hour

Quick Overview

Evaluate electrolyte composition of urine, acid-base balance studies. Distinguish whether or not a case of metabolic alkalosis is chloride-responsive (salt responsive).

Test #003160

$35.00

Availability: In stock

Also Known As Cl, Urine, Urine Cl
Preparation Urinate at 8am and discard the specimen. Then collect all urine in 24-hour period, ending with final collection at 8am the next morning. Refrigerate the collected urine between all voidings or keep it in a cool place. Screw the lid on securely. Transport the specimen promptly to the laboratory. Container must be labeled with full name, date and time collection started, and date and time collection finished.
Test Results 3-5 days. May take longer based on weather, holiday or lab delays.
Evaluate electrolyte composition of urine, acid-base balance studies. Distinguish whether or not a case of metabolic alkalosis is chloride-responsive (salt responsive). Sherman and Eisinger1,2 discuss bicarbonate excretion, blood volume, potassium depletion, and the differential diagnosis of metabolic alkalosis with loss of gastric juice (emesis, intubation) and after diuretics. Chloride depleted patients excrete urine with low chloride, <10 mmol/L. Such patients are chloride-responsive (ie, they respond to chloride sufficient to return body stores to normal). Metabolic alkalosis with low urine chloride is also found with villous tumors of the colon. Endogenous or exogenous corticosteroids produce urine chloride values >20 mmol/L. Such patients are chloride resistant. The finding of chloride resistant metabolic alkalosis may provide a stimulus to identify an ACTH or aldosterone producing neoplasm (eg, Cushing syndrome or Conn syndrome). In Bartter syndrome with metabolic alkalosis, there is usually increased urine chloride. The complex relationships of chronic pulmonary disease with metabolic alkalosis are mentioned by Sherman and Eisinger.

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