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Intrinsic Factor Blocking Antibodies Blood Test

An Intrinsic Factor Blocking Antibodies Blood Test may be used to help determine the cause of a vitamin B12 deficiency and to confirm a diagnosis of pernicious anemia.

Sample Report

Test Code: 010413

Also Known As: Intrinsic Factor Antibody; IF Antibody; IF Antibody Type 1 or Type 2; Intrinsic Factor Binding Antibody; Anti-Intrinsic Factor

Methodology: Immunochemiluminometric assay (ICMA)

Preparation: No fasting required. Samples should not be collected from a patient who has received Vitamin B12 injection therapy within the last week

Test Results: 4-5 days. May take longer based on weather, holiday or lab delays.

Description

An intrinsic factor antibody (IF antibody) test may be used to help determine the cause of a vitamin B12 deficiency and to confirm a diagnosis of pernicious anemia.

It may be ordered when a person has a vitamin B12 deficiency and when pernicious anemia is suspected, as when a person has signs and symptomssuch as:

  • Paleness
  • Weakness, fatigue
  • Numbness and tingling in the feet and/or hands
  • Larger than normal red blood cells (RBCs); sometimes large RBCs are detected before the other signs and symptoms emerge, for example, with a complete blood count (CBC) during routine testing for a health examination.

These findings usually prompt vitamin B12 and folate testing and may lead to methylmalonic acid testing (an early indicator of vitamin B12 deficiency).

When a person has a decreased vitamin B12 level and increased methylmalonic acid and homocysteine levels, an IF antibody test is typically ordered.

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