Quest Test

QuantiFERON TB Gold Blood Test

Quick Overview

An in vitro assay to aid in the diagnosis of both latent and active infection with Mycobacterium Tuberculosis.

Test #19453


Availability: In stock

Also Known As Interferon-gamma Release Assay (IGRA) for Mycobacterium tuberculosis
Preparation No fasting required. This test requires a special collection kit that may not be available at all LabCorp locations. Contact your local LabCorp draw site to verify they have the collection kit in stock before visiting the lab.
Test Results 4-6 days. May take longer based on weather, holiday or lab delays.

The QuantiFERON TB test has been shown to be accurate in HIV-positive individuals with moderately advanced disease, but in the severely immunocompromised the test may be impaired by T-cell anergy.

Active TB disease may result in a negative test as reduction of in vitro IFN-gamma release has been described and may be due to suppressive cytokines associated with TB disease. Patients with mycobacterial infections, other than tuberculosis, might also be responsive to ESAT-6, CFP-10, and TB7.7 as the genes encoding these proteins are present in M kansasii, M szulgai, and M marinum.

Spontaneous interferon-gamma production (independent of TB stimulation) or lack of a response to mitogen (due to anergy or immune suppression) may render the results indeterminate. A negative result should not be used alone to exclude M tuberculosis infection in persons with symptoms or signs suggestive of TB disease. Those who have a negative result, but who are likely to have latent TB infection (LTBI) and who are at greater risk for severe illness or poor outcome if TB disease occurs, might need treatment or closer monitoring for disease.

NOTE:  Transport specimen at room temperature to the laboratory immediately or within 16 hours. 72 hours if preincubated. Special sample collection and transportation arrangements must be made prior to ordering the test. Please contact your local Quest Diagnostics customer service department for specific instructions.

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