Quest Test

Alpha-1 Antitrypsin Blood Test

Quick Overview

Test to help diagnose the cause of early onset emphysema and/or liver dysfunction.

Test #235


Availability: In stock

Also Known As AAT; Acute Phase Proteins; Alpha1-Antitrypsin Serum; Alpha1-Protease Inhibitor; A1AT
Preparation Fasting for 10-12 hours required.
Test Results 1-2 days. May take longer based on weather, holiday or lab delays.

Alpha-1 Antitrypsin testing may be ordered when a person under 40 years of age develops:

  • a chronic cough or bronchitis
  • wheezing
  • shortness of breath after exertion
  • shows other signs of emphysema

This is especially true when the patient has not been exposed to known lung irritants, is not a smoker, and when the lung damage appears to be located low in the lungs.  Alpha-1 Antitrypsin testing may also be done if you have a close relative with alpha-1 antitrypsin deficiency.

Testing is recommended when individuals are diagnosed with certain conditions such as:

  • Emphysema at a young age (younger than 45 years old) and/or no obvious risk factors for the disease, such as smoking
  • Bronchiectasis
  • Asthma that is difficult to treat
  • Liver disease with no known cause
  • A skin disease called panniculitis

Alpha-1-Antitrypsin deficiency has been associated with a number of diseases:

  • Cirrhosis
  • Pelvic organ prolapse
  • COPD
  • Primary sclerosing cholangitis
  • Pneumothorax
  • Autoimmune hepatitis
  • Asthma
  • Wegener's granulomatosis
  • Pancreatitis
  • Gallstones
  • Bronchiectasis
  • Emphysema, predominantly involving the lower lobes and causing bullae
  • Secondary Membranoproliferative Glomerulonephritis
  • Cancer
    • Hepatocellular carcinoma (liver)
    • Bladder carcinoma
    • Gallbladder cancer
    • Lymphoma
    • Lung cancer

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