Quest Test

Alpha-1 Antitrypsin Blood Test

Quick Overview

Test to help diagnose the cause of early onset emphysema and/or liver dysfunction.

Test #235


Availability: In stock

Also Known As AAT; Acute Phase Proteins; Alpha1-Antitrypsin Serum; Alpha1-Protease Inhibitor; A1AT
Preparation Fasting for 10-12 hours required.
Test Results 1-2 days. May take longer based on weather, holiday or lab delays.

Alpha-1 Antitrypsin (AAT) tests may be ordered if a person under 40 years of age develops a chronic cough or bronchitis, wheezing or becomes short of breath after exertion, or shows other signs of emphysema. This is particularly true when the patient is not exposed to known lung irritants, is not a smoker and the lung damage is in the lower lungs. AAT tests can also be done if there is a close relative with a deficiency of Alpha-1 Antitrypsin. 

The American Thoracic Society recommends AAT testing when a diagnosis has been made with conditions such as:

  • Asthma that is difficult to treat
  • Emphysema at a young age (younger than 45 years old) with no apparent risk factors for the disease, such as smoking
  • Liver disease with no known cause
  • Bronchiectasis, airways are stretched or widened
  • Panniculitis, a skin disease, an uncommon complication of AAT deficiency characterized by red, tender nodules on the skin 

Many conditions have been linked to Alpha-1 Antitrypsin deficiency: 

  • Cirrhosis
  • Secondary Membranoproliferative Glomerulonephritis
  • COPD
  • Emphysema
  • Pneumothorax
  • Autoimmune hepatitis
  • Asthma
  • Primary sclerosing cholangitis
  • Wegener's granulomatosis
  • Pelvic organ prolapse
  • Pancreatitis
  • Bronchiectasis
  • Gallstones
  • Cancer
    • Lung cancer
    • Hepatocellular carcinoma (liver)
    • Lymphoma
    • Bladder carcinoma
    • Gallbladder cancer

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