Quest Test

Alpha-1 Antitrypsin Blood Test

Quick Overview

An alpha-1 antitrypsin blood test is integral in defining the cause of early onset emphysema and/or liver dysfunction.

Test #235


Availability: In stock

Also Known As AAT; Acute Phase Proteins; Alpha1-Antitrypsin Serum; Alpha1-Protease Inhibitor; A1AT; Alpha-1 Antitrypsin Deficiency Testing; AAT testing
Preparation Fasting for 10-12 hours required.
Test Results 1-2 days. May take longer based on weather, holiday or lab delays.

The alpha-1 antitrypsin test (AAT) is ordered when a youthful person, usually 40 years of age and under, develop wheezing, bronchitis or a persistent cough, after exertion is short of breath, or there are signs of emphysema. This is particularly true if the patient is a non-smoker, if the damage appears to be in the lower lungs and is not exposed to lung irritants.  

It is recommended that AAT testing is performed when there is a diagnosis of conditions such as: 

  • Hard to treat asthma
  • Emphysema at a young age and there are no risk factors such as smoking
  • Liver disease without an established cause
  • Bronchiectasis, stretched and/or widened airways
  • A skin ailment called panniculitis, an unprecedented complication of AAT insufficiency that is portrayed by red, painful bumps on the skin

Many conditions have been linked to alpha-1 antitrypsin deficiency:

  • Cirrhosis
  • Secondary Membranoproliferative Glomerulonephritis
  • COPD
  • Emphysema
  • Pneumothorax
  • Autoimmune hepatitis
  • Asthma
  • Primary sclerosing cholangitis
  • Wegener's granulomatosis
  • Pelvic organ prolapse
  • Pancreatitis
  • Bronchiectasis
  • Gallstones
  • Cancer
    • Lung cancer
    • Hepatocellular carcinoma (liver)
    • Lymphoma
    • Bladder carcinoma
    • Gallbladder cancer

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