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ADMA/SDMA Blood Test

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The ADMA/SDMA Blood Test measures levels of ADMA/SDMA in individuals at risk for endothelium dysfunction.


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Test Code:


CPT Code(s):



Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)




Fasting is recommended but not required.

Test Results:

7-10 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

What is endothelium dysfunction?

The endothelium is a slim layer of cells that lines the interior of the blood vessels. These cells are always in contact with the blood flow and have a vital role in immunity, blood clotting, and regulating blood pressure. If the endothelium is harmed, it could indicate an elevated risk of cardiovascular disease or renal failure.


What is the purpose of this test?

Order this ADMA/SDMA Blood Test, which measures levels of ADMA/SDMA in individuals at risk for endothelium dysfunction. Compounds called ADMA (asymmetric dimethylarginine) and SDMA (symmetric dimethylarginine) are produced in the body when proteins break down. Unfortunately, both of these compounds can hinder the production of nitric oxide, which is a molecule that helps maintain healthy endothelium. High levels of ADMA and SDMA may indicate endothelial dysfunction or damage due to reduced nitric oxide production.


What factors contribute to abnormal ADMA/SDMA levels?

Several factors may contribute to an increase in the ADMA and SDMA levels, including:


  • An unhealthy diet
  • A sedentary lifestyle
  • High LDL cholesterol 
  • Elevated blood sugar
  • High blood pressure
  • Smoking


All of these factors can cause harm to the delicate endothelial cells that line the blood vessels, leading to the development of cardiovascular diseases such as atherosclerosis and hypertension. Therefore, it's crucial to maintain a healthy lifestyle by consuming a balanced diet, engaging in regular physical activity, avoiding smoking, and managing blood sugar and cholesterol levels to keep the endothelial cells healthy and the blood vessels functioning correctly.


When should I order an ADMA/SDMA Blood Test?

Individuals should check their ADMA/SDMA levels to determine if they have a healthy endothelium. Individuals with poor diet or lifestyle, elevated LDL cholesterol, high blood sugar, high blood pressure, or who smoke should have their ADMA and SDMA levels checked.


  • ADMA can tell an individual if their risk factors may contribute to endothelial damage and increase their likelihood of cardiovascular disease. 
  • SDMA can tell an individual if their risk factors may contribute to an increased likelihood of kidney damage or, in some cases, kidney failure.

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