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Coccidioides Serology Blood Test Panel

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The Coccidioides Serology Blood Test Panel checks for specific antibodies in your blood linked to Coccidioides infections, or Valley fever, caused by fungi in certain soils, using methods like CF and ID to find immune system responses.

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Test Code:

90858

CPT Code(s):

86635(x3)

Methodology:

Complement Fixation (CF) • Immunodiffusion (ID)

Specimen:

Blood

Preparation:

No special preparation required.

Test Results:

2-3 days. May take longer based on weather, holiday or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI


What is the purpose of this test?

The Coccidioides Serology Blood Test Panel, which includes CF Titer, IgG ID (F Antigen), and IgM ID (TP Antigen), is used to detect antibodies in the blood that are specific to Coccidioides infections, also known as Valley fever. Coccidioides are fungi found in the soil of certain regions, and inhaling their spores can cause respiratory infections. This comprehensive panel uses methodologies like Complement Fixation (CF) and Immunodiffusion (ID) to identify antibodies produced by the immune system in response to these fungal infections.

Complement Fixation (CF):

  • Measures the level of antibodies in the blood.
  • Involves mixing patient serum with Coccidioides antigens and complement proteins.
  • Detects specific immune responses to Coccidioides infection.
  • Results indicate the presence and level of antibodies against the fungus.

Immunodiffusion (ID):

  • Identifies specific antibodies against fungal antigens (F Antigen for IgG, TP Antigen for IgM).
  • Involves placing patient serum in a gel with Coccidioides antigens.
  • Antibodies in the serum interact with antigens, forming visible lines (precipitin lines).
  • Results confirm the presence of antibodies against Coccidioides, aiding in diagnosis of Valley fever.

During the test, a blood sample is collected from your arm and sent to a laboratory for analysis. The CF Titer measures the level of antibodies in your blood, while IgG ID (F Antigen) and IgM ID (TP Antigen) specifically detect antibodies against fungal antigens. Positive results indicate exposure to Coccidioides and the development of antibodies, suggesting a current or past infection with Valley fever. This information helps healthcare providers confirm the diagnosis of Valley fever and determine appropriate treatment options, typically involving antifungal medications to manage the infection effectively.

Who should get this test?

The Coccidioides Serology Blood Test Panel is helpful for the following people:

  • Individuals living in or traveling to areas where Coccidioides is commonly found, such as the Southwestern United States
  • People with symptoms suggestive of coccidioidomycosis, such as fever, cough, chest pain, and fatigue
  • Patients with a history of exposure to dust or soil in endemic areas
  • Individuals with weakened immune systems, such as those with HIV/AIDS or taking immunosuppressive medications

When should I order this test?

A Coccidioides Serology Blood Test Panel should be ordered when a person is suspected of having been exposed to the fungus called Coccidioides immitis or Coccidioides posadasii, which can cause an illness called coccidioidomycosis, also known as Valley fever. Symptoms of coccidioidomycosis may include:

  • Fever
  • Cough
  • Chest pain
  • Muscle aches
  • Joint pain
  • Fatigue

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