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Cortisone Blood Test, LC/MS/MS

A Cortisone Blood Test measures Cortisone, a steroidal hormone, a glucocorticoid which is released by adrenal glands. It also has the ability to act as an anti-inflammatory compound and an antidiuretic hormone.

Test Code: 503725

CPT Code: 82542

Also Known As: Compound E


High-pressure liquid chromatography (HPLC)/tandem mass spectrometry

Specimen Type: Blood


No special preparation required.

Test Results:

7-10 days. May take longer based on weather, holiday or lab delays.


Measurement of both Free Cortisol and Cortisone are useful in diagnosing patients with low-renin hypertension caused by apparent mineralocorticoid excess. This may be due to either an inherited defect in 11HSDB2 enzyme or an acquired inhibitor of the enzyme by such compounds as glycyrrhizic acid, a component of natural licorice.

The systematic name of cortisone is 17-hydroxy-11-dehydrocorticosterone. When it comes to glucocorticoid activity, cortisone could be considered as the inactive form of cortisol. Cortisone is activated to become cortisol .

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