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Diphtheria Antitoxoid Blood Test

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The Diphtheria Antitoxoid Blood Test evaluates the effectiveness of diphtheria immunization by measuring antibody levels, ensuring protection against the disease, with levels ≥0.10 IU/mL considered protective.


Test Code:


CPT Code(s):



Immunoassay (IA)




No special preparation is required. 

Test Results:

2-5 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

What is the purpose of this test?

The Diphtheria Antitoxoid Blood Test is a crucial diagnostic tool used to evaluate the immune response to diphtheria immunization. It works by measuring the concentration of antibodies in the blood, which helps determine if an individual has developed sufficient immunity against diphtheria, a potentially harmful bacterial infection. 

This test is particularly useful in identifying individuals who may be vulnerable to diphtheria and require additional immunization. The test results can also be used to monitor the effectiveness of a previous diphtheria vaccine or to determine if an individual needs a booster shot. It's important to note that antibody levels of ≥0.10 IU/mL are considered protective, indicating an adequate immune response. However, a lower antibody level may suggest that an individual is not adequately protected against the diphtheria infection. 

Who would benefit from this test?

The Diphtheria Antitoxoid Blood Test would be beneficial to:

  • Individuals recently vaccinated against diphtheria
  • Healthcare workers
  • Travelers visiting regions where diphtheria is endemic
  • Individuals with weakened immune systems
  • Those who have had contact with someone diagnosed with diphtheria

When should I order a Diphtheria Antitoxoid Blood Test?

A Diphtheria Antitoxoid Blood Test is usually recommended if you have any of the following symptoms:

  • Sore throat
  • Difficulty breathing or swallowing
  • Swollen lymph nodes
  • Weakness or fatigue
  • Fever 
  • Skin rashes 
  • Headache 

It's important to note that these symptoms are not exclusive to diphtheria, and can be caused by a variety of other illnesses as well. If you are experiencing any of these symptoms, it's always best to consult with your healthcare provider for an accurate diagnosis and appropriate treatment plan.

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