What is the purpose of this test?
The Endo+ Hormone – Urine Test from Genova Diagnostics is designed to provide an in-depth evaluation of estrogen metabolism by measuring key estrogen hormones and their metabolites in urine. This test assesses how the body produces, breaks down, and clears estrogens—offering critical insight into hormonal balance and metabolic pathways that influence overall health.
By analyzing urinary estrogen metabolites, this test goes beyond measuring total hormone levels to reveal how estrogens are processed through specific biochemical pathways, including hydroxylation and methylation. These pathways play an important role in hormone balance, detoxification, and long-term health, and disruptions may contribute to symptoms or increased health risks.
Understanding estrogen metabolism patterns helps patients and healthcare providers identify imbalances, assess potential risks related to estrogen dominance, and develop more personalized strategies to support hormonal health and metabolic function.
The Endo+ Hormone – Urine Test Includes:
Urinary Estrogens and Metabolites:
- Estrone, Estradiol, and Estriol: Primary estrogens involved in reproductive health, bone support, and cardiovascular function.
- 2-Hydroxyestrone and 4-Hydroxyestrone: Estrogen metabolites that reflect phase I estrogen metabolism pathways.
- 2-Methoxyestrone and 4-Methoxyestrone: Methylated metabolites that indicate phase II detoxification activity.
- 16-alpha-Hydroxyestrone: A metabolite associated with estrogen activity and tissue exposure.
Optional Add-Ons:
- Salivary sIgA
- Cortisol Awakening Response (CAR)
- Genetic SNP Analysis: COMT, MTHFR, CYP1B1, VDR
- Luteinizing Hormone (LH)
- Follicle-Stimulating Hormone (FSH)
- Prolactin
- Androstenedione
Optional add-ons are sample-specific. Availability depends on whether you choose the saliva, serum (blood), or urine Endo+ Hormone test kit. Only compatible add-ons can be processed with your selected sample type.
Who should get this test?
The Endo+ Hormone – Urine Test is ideal for:
- Individuals experiencing symptoms of estrogen imbalance, such as weight gain, mood changes, or fatigue
- Women navigating premenopause, menopause, or estrogen-related menstrual concerns
- Individuals with a history of estrogen-sensitive conditions or concerns about estrogen metabolism
- Patients seeking deeper insight into hormone detoxification and metabolic pathways
- Those interested in personalized strategies to support hormonal balance and long-term wellness
Benefits of the Endo+ Hormone – Urine Test:
- Advanced Estrogen Metabolism Assessment: Evaluates how estrogens are processed and cleared by the body
- Personalized Insights: Identifies patterns that may guide targeted nutritional and lifestyle interventions
- Metabolic Pathway Clarity: Helps assess phase I and phase II estrogen metabolism balance
- Convenient At-Home Collection: Non-invasive urine sampling
- Actionable Reporting: Provides detailed results to support informed clinical decision-making
Preparation:For accurate results and to avoid delays, collect samples Monday-Thursday and ship the next day after collection.
Test Results:
7 business days once received at lab. May take longer based on weather, holiday, or lab delays.
