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F2-Isoprostane/Creatinine Ratio Urine Test

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The F2-Isoprostane/Creatinine Ratio Urine Test measures oxidative stress levels in a urine sample to help diagnose and monitor various health conditions.


Test Code:


CPT Code(s):



Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)




Overnight fasting is required.

Test Results:

5-6 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

What is the purpose of this test?

The F2-Isoprostane/Creatinine Ratio Urine Test is a diagnostic tool used to measure the body's oxidative stress level. Oxidative stress is a condition that occurs when there is an imbalance between the production of free radicals and the body's ability to counteract or detoxify their harmful effects. 


The F2-isoprostanes are a type of compound that is produced in response to oxidative stress. They are considered reliable oxidative stress markers and are found in various body tissues, including urine. The creatinine level in the urine sample is also measured and used to normalize the F2-isoprostane level. Creatinine is a waste product produced by the muscles in the body and is excreted by the kidneys. 


This test is beneficial for patients because it can help identify the level of oxidative stress in the body, which can indicate various health conditions such as cardiovascular disease, diabetes, and cancer. High levels of oxidative stress have been linked to the development of these conditions, as well as other chronic conditions such as Alzheimer's disease, Parkinson's disease, and arthritis. By detecting these conditions early on, patients can take preventative measures to improve their health outcomes. 


Moreover, the test can also be used to monitor the effectiveness of treatments for these conditions. For instance, if a patient is undergoing cancer or cardiovascular disease treatment, the test can be used to monitor the level of oxidative stress in the body and determine if the treatment is effective in reducing it. Thus, the F2-Isoprostane/Creatinine Ratio Urine Test is a valuable tool for diagnosing and monitoring various health conditions.


What factors cause increased oxidative stress levels?

Several factors can cause increased oxidative stress levels in the body. These include:


  • Exposure to environmental toxins such as air pollution and pesticides
  • A diet high in processed foods and unhealthy fats
  • Chronic stress
  • Lack of exercise
  • Certain medications
  • Aging
  • Certain medical conditions, such as diabetes, cardiovascular disease, and cancer


It is important to adopt a healthy lifestyle that includes a balanced diet, regular exercise, stress management techniques, and avoiding exposure to environmental toxins as much as possible to combat oxidative stress.


When should I order an F2-Isoprostane/Creatinine Ratio Urine Test?

Individuals may order this test if they have experienced symptoms related to increased oxidative stress levels. Common signs or symptoms of high oxidative stress levels include:


  • Fatigue or low energy levels
  • Weakness and muscle pain
  • Headaches
  • Memory loss
  • Premature aging
  • Insomnia
  • Anxiety and depression
  • Digestive problems
  • Increased susceptibility to infections
  • High blood pressure
  • High blood sugar levels
  • Joint pain and inflammation
  • Skin issues such as acne, eczema and psoriasis
  • Vision problems
  • Neurodegenerative diseases such as Alzheimer's and Parkinson's.

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