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Estronex Profile, Urine - Genova Test Kit

The Estronex Profile measures six important estrogen metabolites and their ratios to help women, and even men, assess whether he or she is at risk of developing estrogen sensitive cancers.

Sample Report

Test Code: GD4215

Also Known As: OH Estrogen Ratio


Preparation: 8 hours fasting required. Ship to lab Monday-Thursday only. Please read all of the directions and the collection procedures prior to starting test. Restrict fluid intake to three 8-ounce glasses or less for 24 hours. Make sure no more than 8 ounces are consumed after 8:00 p.m. the evening prior to collection. Empty bladder before going to bed. Collection is preferred on days 18-25 after the start of the menstrual cycle. Do not collect during menstruation. Testing is not recommended during pregnancy.

Test Results: 10-12 days once the lab receives the specimen. May take longer based on weather, holiday or lab delays.


The Estrogen Profile can be used to assess the risk of estrogen sensitive cancers such as uterine, ovarian, cervical, prostate, and head and neck cancers. Many inflammatory conditions also have hormone connections that may be directly related to the improper ratio of 2:16 alpha hydroxyestrone.

The Estronex Profile measures important estrogen metabolites and ratios, including:

The “Good” Estrogen

  • 2-hydroxyestrone (2-OHE1) – high levels of 2-OHE1 are ideal to reduce cancer growth.
  • 2-methoxyestrone (2-MeOE) – 2-MeOE has shown to have anticancer effects and is ideal in high levels.
  • 4-methoxyestrone (4-MeOE) – as a non-cancerous metabolite, 4-MeOE generally does not require treatment at high levels in the body.

The "Bad" Estrogen

  • 4-hydroxyestrone (4-OHE1) – considered a “bad” estrogen, 4-OHE1 levels should be low, as high levels may react negatively with damaged DNA.
  • 16-α-hydroxyestrone (16α-OHE1) – also considered a “bad” estrogen, 16α-OHE1 in high levels may encourage tumor development.

The Ratios

  • 2-OHE1:16α-OHE1 (2:16 ratio) - 2:16 ratios less than 2.0 indicate increasing long-term risk for breast, cervical, and other estrogen sensitive cancers. Importantly, nutritional interventions can help raise Estronex 2:16 ratios and decrease long-term risk. Studies also indicate that this risk is modifiable!
  • 2-OHE1:2-MeOE – a high level of 2-OHE1:2-MeOE may also indicate imbalanced estrogen metabolism and low activity in the COMT gene. Evaluation of methylation activity is recommended.

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