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Intestinal Permeability Urine Assessment Test - Genova Test Kit

An Intestinal Permeability Urine Assessment Test identifies leaky gut and malabsorption.

Test Code: GD2305

Also Known As: Leaky Gut Test kit



8 hours fasting required. Ship to lab Monday-Thursday only. Please read all of the directions and the collection procedures prior to starting test.

Test Results:

7-8 Days once the lab receives the specimen. May take longer based on weather, holiday or lab delays.


This test evaluates digestion, absorption, gut flora, and the colonic environment, and evaluates for parasites using microscopic examination and EIA testing. The profile is indicated for all chronic GI problems, for acute bowel pattern changes, and for many systemic diseases and provides a sensitivity panel for treating pathogenic flora. Specimens must be received in the laboratory within 24 hrs of collection. Tell your healthcare professional if you have an abnormally high glucose level as this will interfere with testing. We CANNOT perform this test on diabetics with >105mg/dl fasting urine glucose concentration. If you have had allergic reactions to foods (including sugarfree foods, beverages, candies, gum, and mints) dietary supplements, dental products, or medicines (prescription and over-the-counter) containing sugar alcohols like sorbitol or xylitol, you should NOT take this test.

This test is also NOT recommended for individuals who have had allergic reactions to lactulose or are on lactose-restricted diet. Certain medications – such as aspirin, other anti-inflammatory drugs, antacids containing aluminum or magnesium hydroxide (eg, Maalox liquid, Equate, Milk of Magnesia, Rolaids, Mylanta) as well as drugs that contain sorbitol and/or mannitol – may affect your test results.

Please let your healthcare professional know about any medications or supplements you are using before taking this test. It is recommended that you avoid the use of these medicines for at least 72 hours before taking this test.

Increased intestinal permeability (leaky gut) of the small intestine can:

  • Increase the number of foreign compounds entering the bloodstream
  • Allow bacterial antigens capable of cross-reacting with host tissue to enter the bloodstream, leading to auto-immune processes
  • Enhance the uptake of toxic compounds that can overwhelm the hepatic detoxification system and lead to an overly sensitized immune system

Leaky gut has been observed in a range of disorders such as:

  • Inflammatory Bowel Disease (IBD)
  • Food allergy
  • Inflammatory joint disease
  • Chronic dermatologic conditions

Studies have demonstrated that the increased intestinal permeability observed in patients with ankylosing spondylitis, rheumatoid arthritis, and vasculitis may be an important factor in the pathogenesis of these disorders.

Decreased permeability, on the other hand, appears as a fundamental cause of malabsorption, subsequent malnutrition, and failure to thrive. In certain disease states of the small intestine, such as gluten-sensitive enteropathy, permeability to large molecules may increase while permeability to small molecules decreases - a result of damage to the microvilli. As a result, nutrients become even less available to assist in the detoxification of antigens flooding the system.

Possible causes of increased intestinal permeability (leaky gut) include:

  • Intestinal infection
  • Ingestion of allergenic foods or toxic chemicals
  • Deficient secretory IgA
  • Trauma and endotoxemia
  • NSAIDs

The Intestinal Permeability Assessment gastrointestinal test directly measures the ability of two non-metabolized sugar molecules to permeate the intestinal mucosa. The patient drinks a premeasured amount of lactulose and mannitol. The degree of intestinal permeability or malabsorption is reflected in the levels of the two sugars recovered in a urine sample collected over the next 6 hours.

•Gel Freezer Pack must be frozen a minimum of 4 hours before shipping.
•The night before the test: Do not eat or drink anything for at least eight hours before beginning this test.
•The day of the test: Do not eat or drink for two hours after taking the test drink. At two hours, drink a glass of water. Drink at least a cup of water every hour until you finish your test. You may eat and drink as usual two hours after taking the test drink; however, you MUST avoid certain foods or beverages, especially those containing fructose (fruit sugar), during the test. Please read all labels to double-check.

These include: • Fruits, fruit juices, jams, jellies, etc. • Soft drinks and foods sweetened with high fructose corn syrup • Any dairy products • Dietetic chocolate • Honey • Mushrooms, beans (legumes including peanuts), celery • Chewing gum

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