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Neopterin/Biopterin Profile (Organix), Urine - Genova Test Kit

The Neopterin/Biopterin Profile measures Neopterin and biopterin which are by-products of the redox reactions involving tetrahydrobiopterin (BH4). BH4 functions as a cofactor for the enzymes responsible for the production of monoamine neurotransmitters (epinephrine, norepinephrine, DOPA, serotonin), and as a cofactor in nitric oxide production.
Sample Report

Test Code: GD3605

Also Known As:


Preparation: No fasting required. Ship to lab Monday-Thursday only. Please read all of the directions and the collection procedures prior to starting test. Restrict fluid intake to three 8-ounce glasses or less for 24 hours. Make sure no more than 8 ounces are consumed after 8:00 p.m. the evening prior to collection. Do not collect during menstruation.

Test Results: 14-16 days once the lab receives the specimen. May take longer based on weather, holiday or lab delays.


Low biopterin levels may reflect insufficient BH4 status. Restricted BH4 cofactor availability has been suggested as an etiologic factor in:

  • Neurological Disease - Alzheimer's Disease, Parkinson's Disease, Autism, Depression, DOPA-responsive Dystonia
  • Insulin Resistance
  • Cardiovascular Disease
  • Inborn-errors of metabolism: Phenylketonuria, Hyperphenylalaninemia

Neopterin is a marker of inflammation, allowing detection and monitoring of inflammatory processes. 

Neopterin is elevated in:

  • Infections
  • Autoimmune diseases: Rheumatoid Arthritis, Systemic Lupus, and Atopic Asthma
  • Malignant diseases
  • Psychiatric disorders
  • Sleep-disordered breathing

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