Oxidative Stress 2.0 Urine Test- Genova Test Kit
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Further, some reactive oxidative species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.
In humans, oxidative stress is thought to be involved in the development of cancer, Parkinson's disease, Alzheimer's disease, atherosclerosis, heart failure,myocardial infarction, fragile X syndrome, Sickle Cell Disease, lichen planus, vitiligo, autism, and chronic fatigue syndrome. However, reactive oxygen species can be beneficial, as they are used by the immune system as a way to attack and kill pathogens. Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis.
Why use the Oxidative Stress 2.0 (Urine) Profile?
Oxidative Stress Analysis 2.0 is a nutritional test used to evaluate the body's oxidative stress status. Normal human metabolism produces highly reactive molecules known as free radicals, typically controlled by antioxidants. When production of free radicals becomes excessive, the antioxidant mechanisms of the cell become overwhelmed, resulting in oxidative damage. The Oxidative Stress 2.0 (Urine) uses a simple urine test to evaluate two key biomarkers of oxidative stress damage.
Effective for Patients Experiencing:
Since oxidative stress can affect cellular function in many body systems, it has been associated with numerous conditions including:
- Chronic Pain/Inflammatory Conditions
- Cardiovascular Disease
- Aging and Neurodegenerative Conditions
About the Oxidative Stress 2.0 (Urine) profile
Biomarkers of oxidative damage can be found in the urine. The Oxidative Stress Analysis 2.0 (Urine) measures these compounds:
- Lipid Peroxides – reflective of oxidative damage to polyunsaturated fatty acids (components of cell membranes)
- 8-OHdG – reflective of oxidative damage to DNA The Oxidative Stress 2.0 Urine test results are displayed using colorimetric reporting, allowing a quick determination of patient need for antioxidant support.
NOTES Female patients should not collect urine during menstruation. Abnormal kidney function or use of diuretics may influence test results. The test should not be performed on individuals with kidney disorder. In addition, certain medicines may impact test results (e.g. cephalosporins such as Cefoxitin, cimetidine such as Tagamet, fibrates such as Ciprofibrate and trimethoprim-sulfamethoxazole such as Bactrim. Let your physician know about your use of these medications. Do not change use of medications unless instructed to do so by your healthcare provider.
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