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Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition

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The Herpes Simplex Virus 2 (IgG), with Reflex to HSV-2 Inhibition test screens for Herpes type 2 and confirms the presence or absence of genital herpes infection.


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Test Code:



Immunoassay (IA)




No special preparation required.

Test Results:

1-3 days. May take longer based on weather, holiday, or lab delays. At this time, the lab is experiencing delays, which could add 5-7 days to the normal turnaround time for reflex test results.


Reflex testing will only report if HSV 2 IGG is >1.09, Positive.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

This test screens for Herpes Simplex Virus (HSV) type 2 by measuring the IgG antibodies that are usually produced within four to twelve weeks of infection and provides confirmatory testing on low positive HSV type 2 results. 

A viral infection produced by the Herpes Simplex Virus (HSV), Herpes causes outbreaks of sores or blisters on different body parts. Of the two types of HSV infections, HSV type 2 is less common. However, HSV type 2 causes the most severe symptoms, such as blisters and sores on the genitals or rectal areas. Therefore, HSV type 2 is commonly referred to as genital herpes.

The Herpes infection is transmitted through direct skin-to-skin or sexual contact with these types of sores. HSV type 2 is often spread through vaginal, oral, or anal sex. Herpes can be passed on even if there are no visible sores. Sometimes, Herpes is transmitted from a parent to a child during fetal development or childbirth. As a result, Herpes is one of the most common sexually transmitted diseases (STD). 

Many individuals infected with HSV do not experience symptoms until two to twenty days after the initial infection. The initial signs and symptoms of an HSV infection may include:

  • Small sores on the skin
  • Blisters around the mouth or lips and on the genitals
  • Tingling, itching, or burning on the skin
  • Fever, headache, or body aches
  • Swollen lymph nodes
  • Less commonly, encephalitis or meningitis, life-threatening brain, and spinal cord infections

Following the initial infection, HSV remains dormant inside the body. However, HSV can reactivate throughout an individual’s life, causing genital or oral herpes symptoms to reoccur. While the stimulus for an HSV outbreak is often unknown, potential triggers include fever, stress, physical trauma, and a compromised immune system.

Individuals may order this if they are experiencing HSV type 2 symptoms, have a sex partner diagnosed with herpes, HIV, or another STD, or for initial screening, confirmation, and continued monitoring. Contact your doctor or healthcare provider if you have significant concerns or questions about your recent lab results.

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