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Histamine Determination Whole Blood Test

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The Histamine Determination Whole Blood Test measures histamine levels in a whole blood sample to help diagnose anaphylaxis, mastocytosis, or mast cell activation.


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Test Code:


CPT Code(s):



Enzyme Immunoassay (EIA)


Whole Blood


No special preparation is required.

Test Results:

2-4 days. May take longer based on weather, holiday, or lab delays

Walk-In Lab is prohibited from selling LabCorp tests to residents in the following states:NY, NJ, RI, MA, MD

What is the purpose of this test?

Order the Histamine Determination Whole Blood Test to measure histamine levels in a whole blood sample to help diagnose anaphylaxis, mastocytosis, or mast cell activation. Histamine is a chemical released from activated mast cells, often as part of an instant immune response. This chemical works as a neurotransmitter and transmits vital signals from the body to the brain. In addition, it also works as a stomach acid component that helps to break down food. 


The Histamine Determination Whole Blood Test, also referred to as histamine intolerance, is not used to determine sensitivity to histamine. Instead, this test helps indicate whether an individual has developed too much histamine in the bloodstream. The following conditions may cause excessive levels of histamine:


  • Anaphylaxis is a life-threatening allergic reaction that triggers symptoms including hives, reddening skin, low blood pressure, trouble breathing, and even death. An anaphylactic response also causes histamine levels to increase quickly in the blood shortly after exposure to allergens. 
  • Mastocytosis is a rare condition associated with the abnormal accumulation of mast cells in the skin and throughout other parts of the body.
  • Mast cell activation is a condition in which individuals experience recurring anaphylaxis symptoms. Mast cells are large tissue cells located all over the body, especially in the skin, intestinal walls, air pathways, and bone marrow. The mast cells contain granules that store chemicals such as histamine and tryptase and release these chemicals when activated as part of the body's immune response to an injury or allergic reaction.


When should I order a Histamine Determination Whole Blood Test?

Because histamine intolerance may affect various body parts and the symptoms can vary, this condition can be challenging to diagnose. However, individuals may order a Histamine Determination Blood Test if they have experienced recurring symptoms related to anaphylaxis. These symptoms may include:


  • Abdominal pain
  • Dizziness
  • Fatigue
  • Flushing
  • Headaches
  • Increased heart rate or pulse
  • Itching or hives
  • Low blood pressure
  • Nasal congestion
  • Nausea or vomiting
  • Sneezing
  • Sore throat
  • Swelling
  • Trouble breathing or wheezing


Which foods or products cause histamine intolerance?

Some foods and products contain large amounts of histamine or cause its release. The following foods and products may cause histamine intolerance:


  • Alcohol
  • Artificial preservatives and dyes
  • Bananas
  • Chocolate
  • Citrus fruits (oranges, grapefruits, and lemons)
  • Cow's milk
  • Fermented dairy products (sour cream, yogurt, and cheese)
  • Fermented vegetables (pickles, sauerkraut, and kimchi)
  • Nuts
  • Papaya
  • Pineapples
  • Shellfish
  • Strawberries
  • Tomatoes
  • Wheat germ

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