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HLA B27 Disease Association Blood Test

A HLA B27 Disease Association Blood Test screens for the presence of HLA-B27 genetic mutations which are associated to different forms of arthritis.

Sample Report

Test Code: 006924

Also Known As: Ankylosing Spondylitis; Disease Association Testing; HLA Antigen B27

Methodology: Polymerase chain reaction (PCR)/sequence-specific oligonucleotide probes (SSOP)

Preparation: No special preparation required.

Test Results: 6-8 days. May take longer based on weather, holiday or lab delays.

Sample Report

Test Code: 528

Also Known As: Ankylosing Spondylitis; Disease Association Testing; HLA Antigen B27

Methodology: Flow Cytometry (FC)

Preparation: No special preparation required.

Test Results: 3-5 days. May take longer based on weather, holiday or lab delays.

Description

HLA-B27 is strongly associated with ankylosing spondylitis (Marie-Strumpell disease). HLA-B27 shares homology with a Klebsiella protein and may imply a bacterial pathogenesis to ankylosing spondylitis. A patient with consistent clinical and radiographic findings who is B27-positive has a greater chance of having or developing ankylosing spondylitis than a negative patient. The antigen is not causative, however, and 10% of normal subjects are B27-positive. This test should not be considered a screening procedure for ankylosing spondylitis. The antigen is less strongly associated with Reiter syndrome and other arthritides than with ankylosing spondylitis. It has been linked with congenital deficiency of C4 and C2, and with adrenal hyperplasia.

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