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IA2 Autoantibodies (Endocrine Sciences)

The IA2 Autoantibodies Test assists in identifying individuals with an increased risk of developing type 1 diabetes or requiring insulin treatment and aids in the classification of diabetes.

Test Code: 141531

CPT Code: 86341

Also Known As: IA2 Antibodies; ICA512 Autoantibodies; Tyrosine Phosphatase Autoantibodies


Enzyme-linked Immunosorbent Assay (ELISA)

Specimen Type: Blood


No special preparation is required.

Test Results:

5-10 days. May take longer based on weather, holiday, or lab delays.


What are IA2 Autoantibodies?

Diabetes is a disease that develops either when the body is not able to make or use insulin appropriately. As a result, the body generates too much blood glucose (sugar) in the bloodstream. 


The two primary types of diabetes are: 

  • Type 1: It happens when the body cannot produce insulin. It is commonly referred to as juvenile diabetes because it is primarily found in children and teenagers. However, type 1 diabetes also affects adults.
  • Type 2: It happens when the body cannot make enough insulin or doesn’t use it as it should. Although type 2 diabetes is primarily found in adults, many children and teenagers are diagnosed with it.


The occurrence of IA2 autoantibodies in people with diabetes suggests that they have autoimmune diabetes (type 1 diabetes). Type 1 diabetes is an autoimmune disease since the lack of insulin stems from an immune response that destroys the insulin-producing beta cells in the pancreas. Approximately 60% of individuals with new-onset type 1 diabetes have IA2 autoantibodies. These antibodies are also helpful in diagnosing latent autoimmune diabetes in adulthood (LADA). A positive result for IA2 autoantibodies in asymptomatic individuals or those with a family history may indicate an increased risk of developing type 1 diabetes. In addition, the presence of IA2 autoantibodies in the blood of patients who have received a pancreas transplant may indicate potential beta-cell failure.


What is the purpose of this test?

Order this IA2 Autoantibodies Test to help assess the risk of developing type 1 diabetes or distinguishing the class of diabetes. This IA2 autoantibody test may also evaluate the potential need for insulin treatment in patients with adult-onset diabetes. 


When should I order an IA2 Autoantibodies Test?

Individuals may order this test if they have experienced symptoms related to type 1 diabetes. Signs or symptoms of type 1 diabetes may include:

  • Dry mouth
  • Frequent urination
  • Constant hunger
  • Fatigue
  • Weight loss
  • Slow-healing sores or wounds
  • Dry or itchy skin
  • Numbness or tingling in your feet
  • Blurry vision

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