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Walk-in-lab Test Kit: ImmunoGenomic® Buccal Swab Profile - Genova Test Kit

ImmunoGenomic® Buccal Swab Profile - Genova Test Kit - NOT CURRENTLY AVAILABLE

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The ImmunoGenomic® Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs), in genes that modulate immune and inflammatory activity.

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Polymorphisms affect the levels and activity of the cytokines. These variations can affect balance between cell-mediated (TH-1) and humoral (TH-2) immunity, reveal potential defects in immune system defense, and stimulate mechanisms leading to chronic, overactive inflammatory responses.

 

The test uncovers potential genetic susceptibility to:

• Asthma

• Autoimmune Disorders

• Certain Cancers

• Allergy

• Infectious Diseases

• Bone Inflammation

• Arthritis

• Inflammatory Bowel Disease

• Heart Disease

• Osteopenia

• Helicobacter pylori infection (cause of ulcers)

 

Chronic Inflammation

• IL-1ß (interleukin-1beta)

 

This gene affects the duration and intensity of the acute inflammatory response. The polymorphism leads to increased production of IL-1B, hypochlorhydria, increased susceptibility to H. pylori infection, and gastritis and gastric cancer in H. pylori-infected individuals.

 

TH-1 Cytokines (Viral Infection & Cancer)

• TNF-a (tumor necrosis factor-alpha)

 

Polymorphisms of this gene affect cell-mediated immunity, increasing production of the pro-inflammatory cytokine TNF-alpha. This can promote or exacerbate chronic conditions such as arthritis, osteoporosis, and asthma.

 

TH-2 Cytokines (Allergy, Asthma, and Atopy)

• IL-4 (interleukin-4)

• IL-6 (interleukin-6)

• IL-10 (interleukin-10)

• IL-13 (interleukin-13)

 

TH-2 cytokines promote humoral immunity, including the synthesis of IgE. They are generally regarded as anti-inflammatory; however, excessive activity of some of these cytokines may promote the development of allergic conditions such as atopy, asthma, and hypersensitivity. Low levels may result in chronic inflammatory conditions characterized by a TH-1 response. IL-6 has both pro- and anti-inflammatory properties; this cytokine drives the acute phase response and can promote chronic inflammation and progression in autoimmune disease.

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