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ImmunoGenomic® Buccal Swab Profile - Genova Test Kit - NOT CURRENTLY AVAILABLE

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The ImmunoGenomic® Profile evaluates genetic variations, called single nucleotide polymorphisms (SNPs), in genes that modulate immune and inflammatory activity.

Polymorphisms affect the levels and activity of the cytokines. These variations can affect balance between cell-mediated (TH-1) and humoral (TH-2) immunity, reveal potential defects in immune system defense, and stimulate mechanisms leading to chronic, overactive inflammatory responses.


The test uncovers potential genetic susceptibility to:

• Asthma

• Autoimmune Disorders

• Certain Cancers

• Allergy

• Infectious Diseases

• Bone Inflammation

• Arthritis

• Inflammatory Bowel Disease

• Heart Disease

• Osteopenia

• Helicobacter pylori infection (cause of ulcers)


Chronic Inflammation

• IL-1ß (interleukin-1beta)


This gene affects the duration and intensity of the acute inflammatory response. The polymorphism leads to increased production of IL-1B, hypochlorhydria, increased susceptibility to H. pylori infection, and gastritis and gastric cancer in H. pylori-infected individuals.


TH-1 Cytokines (Viral Infection & Cancer)

• TNF-a (tumor necrosis factor-alpha)


Polymorphisms of this gene affect cell-mediated immunity, increasing production of the pro-inflammatory cytokine TNF-alpha. This can promote or exacerbate chronic conditions such as arthritis, osteoporosis, and asthma.


TH-2 Cytokines (Allergy, Asthma, and Atopy)

• IL-4 (interleukin-4)

• IL-6 (interleukin-6)

• IL-10 (interleukin-10)

• IL-13 (interleukin-13)


TH-2 cytokines promote humoral immunity, including the synthesis of IgE. They are generally regarded as anti-inflammatory; however, excessive activity of some of these cytokines may promote the development of allergic conditions such as atopy, asthma, and hypersensitivity. Low levels may result in chronic inflammatory conditions characterized by a TH-1 response. IL-6 has both pro- and anti-inflammatory properties; this cytokine drives the acute phase response and can promote chronic inflammation and progression in autoimmune disease.

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