Intrinsic Factor Blocking Antibody Blood Test

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The Intrinsic Factor Blocking Antibody Blood Test checks for antibodies that can stop the body from absorbing vitamin B12, helping to diagnose pernicious anemia.

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What is the purpose of this test?

The Intrinsic Factor Blocking Antibody Blood Test helps detect antibodies that interfere with the absorption of vitamin B12 in the body. Intrinsic factor is a protein produced in the stomach that binds to vitamin B12, allowing it to be absorbed in the intestines. When the immune system mistakenly creates antibodies against intrinsic factor, it can lead to vitamin B12 deficiency and cause a condition known as pernicious anemia.

This test is essential for diagnosing pernicious anemia and understanding the cause of unexplained vitamin B12 deficiency. Early detection is crucial since prolonged B12 deficiency can lead to neurological issues, fatigue, and other health complications. By measuring intrinsic factor blocking antibodies, this test helps doctors determine whether a patient’s vitamin B12 deficiency is due to an autoimmune response, guiding appropriate treatment options.

Who should get this test?

Individuals with symptoms of vitamin B12 deficiency, such as fatigue or weakness.
Those diagnosed with anemia or unexplained low vitamin B12 levels.
People experiencing neurological symptoms like numbness, tingling, or difficulty walking.
Individuals with a family history of pernicious anemia or autoimmune disorders.
Those following a vegetarian or vegan diet who may be at risk for B12 deficiency.
Patients with digestive disorders, such as celiac or Crohn’s disease, that affect nutrient absorption.

When should I order the Intrinsic Factor Blocking Antibody Blood Test?

Individuals may consider ordering this test if they have symptoms or concerns related to vitamin B12 deficiency. Symptoms to consider:

Persistent fatigue or weakness.
Numbness, tingling, or loss of coordination.
Pale or jaundiced skin.
Shortness of breath or dizziness.
Difficulty concentrating or memory issues.
Swollen or inflamed tongue.

If you have these symptoms or suspect a vitamin B12 absorption issue, the Intrinsic Factor Blocking Antibody Blood Test can provide valuable information to guide you and your doctor in diagnosing and managing your health.

LC Sample Report QD Sample Report

Notice: This is a sample report. Reporting format and ranges are subject to change. Contact us with any questions or concerns.

CPT Code(s): 86340

Test Code(s):

010413, 568

Also Known As:

Intrinsic Factor Antibody; IF Antibody; IF Antibody Type 1 or Type 2; Intrinsic Factor Binding Antibody; Anti-Intrinsic Factor

Specimen:

Blood

Preparation:

Fasting is not required. Samples should not be collected from patients who have received Vitamin B12 injection therapy within the past week.

Test Results:

4-5 days. May take longer based on weather, holiday, or lab delays.

Details:

LabCorp Only: Reports results as a numerical value, providing a quantitative measurement of intrinsic factor blocking antibodies.

Other Laboratories: Reports results as either positive or negative, offering a qualitative assessment of the presence of intrinsic factor blocking antibodies. (Not Included with LabCorp)