Quick Facts
- Sample: Blood (serum)
- Fasting: 8–12 hours recommended
- Turn-around: 1–2 business days. May take longer based on weather, holiday, or lab delays.
Benefits
- Early detection of liver problems before symptoms appear
- Comprehensive assessment of liver function with 7 key biomarkers
- Convenient ordering with no doctor visit required
- Confidential results delivered securely online
- Monitor medication effects on liver health
- Track chronic conditions and treatment progress
Who Is This Test For?
- Individuals with family history of liver disease
- People taking medications that may affect liver function
- Those with symptoms like fatigue, jaundice, or abdominal pain
- Individuals with high-risk behaviors (alcohol use, hepatitis exposure)
- Anyone seeking baseline liver health assessment
- Patients monitoring known liver conditions
How It Works – Just 3 Steps
- Order online - Purchase your test with no doctor referral needed
- Visit lab - Get your blood drawn at a convenient partner location
- Get results - Access your confidential results online in 1-2 days
FAQ
Do I need to fast before this test? Yes, fasting for 8-12 hours is recommended. Water is permitted during the fasting period.
What does this test measure? It measures 7 key liver biomarkers including cholesterol total, hepatic function panel, LD, GGT, prothrombin time-INR & PT, CBC with Differential and Platelets, and AFP.
How accurate is this test? ALT and AST elevations have 85-95% sensitivity for detecting liver cellular injury (PathologyOutlines.com 2021).
Can I take my medications before the test? Continue regular medications unless instructed otherwise. Stop biotin supplements 72 hours before testing.
What if my results are abnormal? Share abnormal results with your healthcare provider for proper evaluation and follow-up recommendations.
How often should I repeat this test? Generally every 6-12 months for chronic monitoring, depending on your risk factors and findings.
More Details
What is the purpose of this test?
The Liver Profile #2 Essential Blood Test Panel evaluates liver health by measuring specific enzymes, proteins, and byproducts that indicate liver function and damage. This comprehensive panel screens for liver disease, monitors existing conditions, and assesses how medications or lifestyle factors affect your liver (Mayo Clinic 2025).
Liver disease affects approximately 4.5 million adults in the U.S.—about 1.8% of the population (CDC 2024). Early detection is crucial since about 40% of people with chronic liver disease remain asymptomatic until advanced stages (Cleveland Clinic 2025).
Who would benefit from this test?
This test benefits anyone concerned about liver health, especially those with risk factors or symptoms. Key candidates include individuals with family history of liver disease, people taking hepatotoxic medications, those with viral hepatitis exposure, and anyone experiencing symptoms like fatigue, jaundice, or abdominal discomfort.
Healthcare providers also recommend this panel for monitoring chronic liver conditions, evaluating treatment effectiveness, and establishing baseline liver function for future comparison (MedlinePlus 2023).
When should I order the Liver Profile #2 Essential Blood Test Panel?
Order this test if you have symptoms suggesting liver dysfunction, take medications affecting liver function, have chronic health conditions, or want baseline wellness data. It's also valuable for routine health screening, especially if you have risk factors like alcohol use or family history of liver disease.
Consider testing before starting new medications known to affect the liver, or as part of regular health monitoring every 6-12 months if you have ongoing risk factors (Cleveland Clinic 2025).
How do I interpret the results?
Your results will show each biomarker level compared to normal reference ranges. The report indicates whether values are normal, high, or low. However, interpretation requires clinical context—not all abnormalities indicate disease.
ALT (SGPT):
- 7–45 U/L
- Elevation may indicate liver cell damage or hepatitis
AST (SGOT):
- 8–40 U/L
- Elevation may indicate liver or muscle damage
Alkaline Phosphatase:
- 44–147 U/L
- Elevation may indicate liver or bone disease
Total Bilirubin:
- 0.2–1.2 mg/dL
- Elevation may indicate liver dysfunction or bile duct issues
Albumin:
- 3.5–5.0 g/dL
- Low levels may suggest liver disease
Significant abnormalities, especially in ALT/AST or bilirubin, should prompt medical evaluation for proper diagnosis and treatment planning.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
Pre-test preparation
Fast for 8-12 hours before your test—water is permitted during fasting. Avoid alcohol for at least 24 hours and stop biotin supplements 72 hours prior to testing. Continue taking regular medications unless your healthcare provider advises otherwise.
Schedule your test for morning hours when possible, as this timing provides the most accurate fasting results (Quest Diagnostics 2025).
How often should I get tested?
Testing frequency depends on your individual risk factors and health status. Here are general guidelines:
- Healthy adults (screening) → Every 2–3 years
- High-risk individuals → Every 6–12 months
- Chronic liver disease → Every 3–6 months
- New hepatotoxic medications → Baseline, then as directed
- Abnormal previous results → As recommended by provider
Why early detection matters
Early liver disease detection can prevent progression to serious complications like cirrhosis or liver cancer. When detected early, lifestyle changes and treatment can reduce severe complications by more than 50% (Mayo Clinic 2025).
The liver has remarkable regenerative capacity when damage is caught early. Silent liver disease progression makes regular screening especially important for at-risk individuals, as symptoms often don't appear until significant damage occurs.
Related tests you may consider
Comprehensive Metabolic Panel (CMP-14) - Provides broader metabolic assessment including kidney function, electrolytes, and glucose for complete health picture.
Hepatitis Panel - Essential for identifying viral causes of liver dysfunction, especially with abnormal liver enzymes.
Lipid Panel - Often ordered alongside liver tests since the liver plays a key role in cholesterol metabolism.
