Quick Facts
- Sample: Blood
- Fasting: No special preparation required
- Turnaround: 5-7 business days. May take longer based on weather, holiday, or lab delays.
What This Test Measures
The Methylated Septin 9 blood test detects the methylated Septin 9 gene in a blood sample. This single biomarker is used to screen for colorectal cancer, which develops when polyps form in the lining of the large intestine, in the colon or rectum. The test looks for a specific methylation pattern in the Septin 9 gene rather than measuring a protein or antigen level.
This test is intended as a screening tool. It is not a diagnostic test, and it does not confirm whether colorectal cancer is present. It also does not rule out colorectal cancer if the result is normal. A positive or abnormal result may prompt further evaluation by a healthcare provider, which could include additional testing such as colonoscopy.
Benefits
- Screens for colorectal cancer using a simple blood draw
- Detects the methylated Septin 9 gene associated with colorectal cancer
- Offers a screening option for people who prefer a blood test
- Requires no special preparation before testing
- Supports earlier screening conversations with your healthcare provider
- Results are delivered online for convenient access
Who Is This Test For?
- Adults who want to begin colorectal cancer screening earlier than standard guidelines
- People with a family history of colorectal cancer
- Individuals who previously had colorectal polyps
- People with a personal or family history of ovarian cancer
- Those with inflammatory bowel disease, such as ulcerative colitis or Crohn's disease
- People with lifestyle risk factors, such as a high-fat diet or smoking
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this test?
This test measures the methylated Septin 9 gene in a blood sample to screen for colorectal cancer. It may help a healthcare provider evaluate whether further testing, such as colonoscopy, should be considered. This test does not diagnose colorectal cancer on its own and should be used alongside guidance from a qualified healthcare provider.
2. Who may benefit from this test?
This test may be considered by people who want to begin colorectal cancer screening before the standard recommended age, as well as those with a family history of colorectal cancer, a personal history of colorectal polyps, a personal or family history of ovarian cancer, inflammatory bowel disease, or lifestyle risk factors such as a high-fat diet or smoking. It is not intended for everyone concerned about cancer, and eligibility should be discussed with a healthcare provider.
3. How does this test differ from other cancer-related tests?
Unlike stool or imaging-based methods, this test uses a blood sample as an approach to colorectal cancer screening. It detects the methylated Septin 9 gene rather than other biomarkers, proteins, antigens, or genes, and it is not a panel of multiple markers. The source does not compare its performance directly with other screening methods.
4. Do I need to fast before this test?
No special preparation is required for this test.
5. How quickly will I get results?
Results are typically available in 5 to 7 business days. Turnaround may take longer based on weather, holidays, or lab delays.
6. How do I interpret the results?
An abnormal result for the methylated Septin 9 gene does not automatically mean colorectal cancer is present, and a normal result does not automatically rule out colorectal cancer. Interpretation depends on the specific finding, your medical history, and your overall clinical picture. Your healthcare provider may consider the result alongside other clinical information, such as symptoms, risk factors, or additional testing, when deciding on next steps.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
7. What should I do if my results are abnormal?
Review an abnormal result with a qualified healthcare provider. Your provider may recommend additional evaluation based on your individual health history and the result.
8. How often should I get tested?
Testing frequency is best determined by your healthcare provider based on your individual risk factors and screening history. Medical groups vary in their recommended starting age for colorectal cancer screening, with some recommending age 50 and others recommending age 45. Discuss the right screening schedule for you with your healthcare provider.
Pre-test preparation
No special preparation is required for this test.
