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Methylated Septin 9 Blood Test

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The Methylated Septin 9 blood test screens for colorectal cancer.


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Test Code:


CPT Code(s):


Also Known As:

Methylated Septin 9 DNA; Methylated SEPT9 DNA; SEPT9


Real-Time Polymerase Chain Reaction (PCR)




No special preparation required.

Test Results:

9-12 days. May take longer based on weather, holiday or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

The Methylated Septin 9 test screens colorectal cancer by detecting the methylated Septin 9 gene in blood samples. Colorectal cancer develops when polyps form in the lining of the large intestine, starting in the colon or rectum. Colorectal cancer is common in women and men, especially those 50 and older.

The chief cause of cancer-related deaths in the United States is colorectal cancer. Early screening can help find colorectal cancer early when treatment is most effective. In addition, Colorectal cancer screening can sometimes prevent cancer from even developing. Screening tests may help a health care provider detect and remove abnormal growths, known as colorectal polyps. Most of these polyps are noncancerous but risk becoming cancerous if not removed.

Medical expert groups such as The National Cancer Institute recommend people screen for colorectal cancer regularly, starting at age 50. However, the American Cancer Society recommends that people begin screening as early as age 45. You should contact your health care provider to determine when to start screening for colorectal cancer and discuss the appropriate screening test.

You may order the Methylated Septin 9 test if you would like to start screening at an early age or if you meet certain health risk factors, including:

  • Family history of colorectal cancer
  • Previously had colorectal polyps
  • Family history of, or having had, ovarian cancer
  • Inflammatory bowel diseases such as ulcerative colitis or Crohn's disease
  • Eat a diet high in fat
  • Smoke

Common symptoms of colorectal cancer may include:

  • Diarrhea or constipation
  • Incomplete bowel movements
  • Bloody stools
  • Narrow stools
  • Excess gas or cramps, or feeling full or bloated
  • Weight loss for no known reason
  • Fatigue
  • Nausea or vomiting



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