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Myasthenia Gravis Antibody Profile

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The Myasthenia Gravis Antibody Profile detects specific autoantibodies that diagnose Myasthenia Gravis (MG). A reflex titer is performed for positive Striated Muscle Antibody results.


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No special preparation is required.

Test Results:

5-10 days. May take longer based on weather, holiday, or lab delays.


This test includes a reflexive Striated Muscle Antibody Titer test on positive Striated Muscle Antibody Screen results.

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What is the purpose of this test?

The Myasthenia Gravis Antibody Profile is a group of blood tests used to diagnose Myasthenia Gravis (MG), a neuromuscular disorder that causes weakness and fatigue in the muscles that control eye movements, facial expressions, chewing, swallowing, and speaking. The panel typically includes tests for antibodies that may be present in people with MG, such as Acetylcholine Receptor Binding Antibodies, Acetylcholine Receptor Blocking Antibodies, Acetylcholine Receptor Modulating Antibodies, and Striated Muscle Antibodies. Doctors may also order other blood tests, such as a complete blood count (CBC), erythrocyte sedimentation rate (ESR), and liver and kidney function tests, to rule out other possible causes of muscle weakness and fatigue. The results of these blood tests can help doctors confirm a diagnosis of MG and determine the best course of treatment.


The Myasthenia Gravis Antibody Profile includes the following:

Acetylcholine Receptor Binding Antibody - Acetylcholine Receptor Binding Antibody is a type of antibody in the blood that can attack and bind to the acetylcholine receptors in the body. These receptors are important for muscle movement and if they are attacked by the antibodies, it can cause muscle weakness and fatigue.

Acetylcholine Receptor Blocking Antibody - Acetylcholine Receptor Blocking Antibody is a type of antibody that can attack the acetylcholine receptors in the body. These receptors are responsible for transmitting signals between the nerves and muscles. When these antibodies attack the receptors, they can cause muscle weakness and other symptoms.

Acetylcholine Receptor Modulating Antibody - Acetylcholine Receptor Modulating Antibodies are proteins that can affect the function of acetylcholine receptors in the body. These receptors are important for the transmission of nerve impulses, and when they are affected by these antibodies, it can lead to muscle weakness and other symptoms.

Striated Muscle Antibody - Striated Muscle Antibody (SMA) is an antibody that targets the proteins found in the muscles that we use to move our body voluntarily. These proteins are called actin and myosin. High levels of SMA can indicate an autoimmune disorder, such as myasthenia gravis or systemic lupus erythematosus (SLE), which can cause muscle weakness and fatigue.


Benefits of the Myasthenia Gravis Antibody Profile:

  1. Accurate diagnosis: This profile aids in accurately diagnosing myasthenia gravis by detecting specific autoantibodies present. This is crucial for initiating appropriate treatment and management strategies.
  2. Differential diagnosis: Testing for myasthenia gravis antibodies can help differentiate it from other neuromuscular disorders with similar symptoms. This aids in ruling out alternative diagnoses and ensuring appropriate management.
  3. Treatment guidance: The results of the Myasthenia Gravis Antibody Profile can assist healthcare providers in selecting the most effective treatment options for patients based on their antibody profile. 
  4. Monitoring disease activity: Following the initial diagnosis, regular testing with this panel allows for monitoring antibody levels over time. This helps assess disease activity, treatment response, and disease progression, guiding adjustments in management as needed.
  5. Personalized management: This profile enables personalized treatment plans tailored to each patient's specific needs and disease characteristics by providing detailed information about antibody status.


When should I order a Myasthenia Gravis Antibody Profile?

Individuals should consider ordering a Myasthenia Gravis Antibody Profile if they experience any of the following symptoms:

  • Muscle weakness in the eyes, face, throat, or limbs
  • Double vision
  • Difficulty swallowing, chewing, or speaking
  • Drooping eyelids
  • Fatigue
  • Shortness of breath
  • Hoarseness

It is important to note that these symptoms can also be present in other health conditions, so it is always best to consult with a healthcare professional to determine if a myasthenia gravis blood test is necessary.

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