Platelet Antibody Profile
The Platelet Antibody Profile measures antiplatelet antibody levels in a blood sample.
This test measures antiplatelet antibody levels to help screen for blood disorders that cause abnormally low platelet counts. The immune system makes antibodies to help combat infected cells or tissues, referred to as antigens (bacteria or viruses). However, certain blood disorders may cause these antibodies to target healthy cells and tissues.
Platelets are an essential part of the blood that clumps together to help with clotting when blood vessels are injured. Antiplatelet antibodies are antibodies that target and destroy platelets. These antibodies cause your blood to have an abnormally low platelet count, a condition known as thrombocytopenia. Low platelet levels are also be related to other blood disorders, such as:
- Immune thrombocytopenic purpura (ITP)
- Thrombotic thrombocytopenic purpura (TTP)
- Post-transfusion purpura (PTP)
- Infection with Hepatitis C virus, HIV, or Epstein-Barr virus
Other signs or symptoms of thrombocytopenia may include:
- Excessive bleeding
- Bleeding in the mouth and gums
- Skin rash (pinpoint red spots)
- Abnormally heavy menstrual flow
- Muscle weakness
This test screens five common types of antiplatelet antibodies, including:
- HLA Class 1
- Glycoprotein (GP) IV
Individuals may order this test to help diagnose a blood disorder that causes platelet dysfunction, monitor platelet function, screen at-risk pre-surgical patients, or to monitor antiplatelet therapy.
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