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Rheumatoid Factor IGA, IGG, IGM Blood Test

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The Rheumatoid Factor (IgA, IgG, IgM) Blood Test helps diagnose rheumatoid arthritis and other autoimmune disorders by detecting and measuring 3 rheumatoid factors in a blood sample.


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Test Code:


CPT Code(s):



Immunoassay (IA)




Fasting overnight is required.

Test Results:

3-6 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

The Rheumatoid Factor (IgA, IgG, IgM) Blood Test measures the following biomarkers:

  • Rheumatoid Factor (IgA)
  • Rheumatoid Factor (IgG)
  • Rheumatoid Factor (IgM)


What is the purpose of this test?

Order this Rheumatoid Factor (IgA, IgG, IgM) Blood Test, which aids in the prognosis of rheumatoid arthritis and other autoimmune disorders by detecting and measuring three rheumatoid factors present in a blood sample. Rheumatoid factors are proteins produced by the immune system. Typically, your immune system creates antibodies to combat harmful germs that can cause illnesses. However, rheumatoid factors are antibodies that can mistakenly attack healthy cells and tissues within your body. This can result in an autoimmune disorder.


It's important to note that not everyone has rheumatoid factors in their blood, and some individuals with these factors are still healthy. However, if you are experiencing specific symptoms alongside elevated levels of rheumatoid factors, it may indicate an autoimmune disorder or another health issue related to high RF levels.


RF testing serves as a supplementary diagnostic tool for rheumatoid arthritis alongside other tests. Rheumatoid arthritis is an autoimmune condition that harms joints resulting in discomfort, inflammation, and rigidity. It is a persistent ailment that can impact your organs and lead to additional symptoms. Elevated levels of rheumatoid factors can also be a sign of other autoimmune conditions, specific infections, and particular types of cancer.


What conditions are related to abnormal RF levels?

Several underlying conditions may cause high levels of rheumatoid factors, such as:


  • Sjögren syndrome
  • Lupus
  • Scleroderma
  • Juvenile idiopathic arthritis in children and teens
  • Chronic infections, including:
  • Hepatitis C (liver)
  • Tuberculosis (primarily affects the lungs)
  • Endocarditis (heart)
  • Certain types of cancer, including leukemia


When should I order a Rheumatoid Factor (IgA, IgG, IgM) Blood Test?

Individuals may order this test if they have symptoms of rheumatoid arthritis. These symptoms typically manifest in the wrists, hands, and feet, often affecting the same joints on both sides of the body. Additionally, the symptoms tend to occur intermittently. Common signs or symptoms of rheumatoid arthritis may include:


  • Joint pain
  • Tenderness, swelling, and warmth of the joint
  • Joint stiffness that lasts longer than 30 minutes
  • Fatigue
  • Occasional low fevers
  • Loss of appetite
  • Problems outside of the joints may include dry eyes or mouth, firm lumps under the skin, or anemia

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