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RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing

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The RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing screens for syphilis by detecting antibodies to the Treponema pallidum bacterium and, if reactive, to further quantify antibody levels and confirm the diagnosis through additional testing.

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What is the purpose of this test?

The RPR (Rapid Plasma Reagin) test is a screening test used to detect syphilis, a sexually transmitted infection caused by the bacteria Treponema pallidum. The RPR test works by detecting antibodies in the blood that are produced in response to the infection.

If the RPR test is positive, a reflex to titer and confirmatory testing is usually done. The titer test measures the level of antibodies in the blood, which can help determine the stage of the infection and guide treatment decisions. Confirmatory testing, such as the treponemal-specific test, is used to confirm the diagnosis of syphilis and differentiate it from other conditions that can cause false-positive RPR results.

Overall, the purpose of the RPR with reflex to titer and confirmatory testing is to accurately diagnose syphilis and guide appropriate treatment to prevent further complications.

Who would benefit from this test?

RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing is beneficial to:

Individuals who may have been exposed to syphilis
Pregnant women
Individuals with HIV
Individuals who engage in high-risk sexual behaviors
Individuals who are undergoing treatment for syphilis
Healthcare providers who are involved in the diagnosis and treatment of syphilis

When should I order RPR (Diagnosis) with Reflex to Titer and Confirmatory Testing?

The RPR test with reflex to titer and confirmatory testing should be ordered for patients exhibiting the following symptoms:

Unexplained fever
Skin rash or sores
Joint pain
Muscle aches
Swollen lymph nodes
Sore throat
Fatigue
Hair loss
Headache
Weight loss
Nausea, vomiting, or diarrhea
Eye redness, pain, or blurred vision

It's important to note that these symptoms can be indicative of a number of different conditions, and a positive RPR test does not necessarily mean that a patient has syphilis. Confirmatory testing should always be performed to ensure an accurate diagnosis.

LC Sample Report QD Sample Report

CPT Code(s): 86592

Test Code(s):

36126, 012005

Also Known As:

Premarital RPR,Syphilis Serology Screen, Blood,ART,Rapid Plasma Reagin,Automated Reagin Test

Specimen:

Blood

Preparation:

No special preparation is required.

Test Results:

2-3 days. May take longer based on weather, holiday, or lab delays.

Details:

(LabCorp Only) This test includes a reflexive quantitative RPR and a Treponema pallidum antibody test when the initial RPR screen is reactive. An interpretation will also be included with results to support clinical decision-making. Note that this syphilis screening may not detect early or late-stage infections. Please consult a healthcare provider if you have symptoms or believe you may have been exposed.

(Not Included with LabCorp)False positive results may occur due to conditions such as systemic lupus erythematosus, leprosy, brucellosis, atypical pneumonia, typhus, yaws, pinta, or pregnancy. Regular monitoring of RPR is useful for evaluating the effectiveness of treatment.