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Scleroderma (SCL-70) Blood Test

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The Scleroderma (Scl-70) Antibody test measures the Scl-70 antibodies in the blood to help diagnose progressive systemic sclerosis (scleroderma).


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Test Code:


CPT Code(s):



Immunoassay (IA)




No special preparation required.

Test Results:

3-5 days. May take longer based on weather, holiday or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

Order this Scleroderma (Scl-70) Antibody test to measure the Scl-70 antibodies in the blood to help diagnose progressive systemic sclerosis. Progressive systemic sclerosis is also known as scleroderma. Scleroderma is a chronic autoimmune connective tissue disease that triggers the hardening and tightening of the skin. In addition, it generates inflammation and damage to the blood vessels, intestines, and other internal organs.

The cause of scleroderma is still being researched. However, many researchers believe it results from an immune system disorder that triggers an overproduction and buildup of collagen in body tissues. Therefore, scleroderma is widely thought to be an autoimmune disease, and individuals with it frequently have other autoimmune disorders such as rheumatoid arthritis or Sjogren's syndrome. Other factors associated with the development of scleroderma include family history, genetics, exposure to certain toxic substances, and chronic sickness. As a result, scleroderma can impact people in a variety of ways.

Common symptoms associated with scleroderma include:

  • Developing patches of hardened, tightened skin, fingers, or toes that turn blue and numb in cold temperatures
  • Red spots on the face and hands
  • Bloating
  • Heartburn
  • Cramping
  • Diarrhea
  • Constipation

When scleroderma spreads to other organs, it can cause further health complications that have long-term effects, such as:

  • Loss of lung capacity
  • Heart failure
  • High blood pressure
  • Chronic digestive issues
  • Sexual dysfunction
  • Kidney disease
  • Loss of blood flow to fingers or toes, which may necessitate amputation

Individuals may order this test if they have signs or symptoms of scleroderma and to help diagnose or monitor the disease's activity or progression.

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