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Scleroderma (SCL-70) Blood Test

The scleroderma blood test looks for Scl-70 antibodies in a blood sample. Scleroderma antibodies (Scl-70) are found in patients with progressive systemic sclerosis (scleroderma).

Test Code: 4942

Also Known As: Antiscleroderma 70 Antibodies; Anti-Scl 70

Methodology: Immunoassay (IA)

Preparation: No special preparation required.

Test Results: 3-5 days. May take longer based on weather, holiday or lab delays.


Order a scleroderma blood test to look for Scl-70 antibodies in a blood sample. Anti-Scl 70 antibodies are commonly linked to scleroderma, a connective tissue disease that affects the skin as well as other tissues such as organs, the gastrointestinal tract, and blood vessels. The causes of scleroderma are still being researched. Scleroderma is widely thought to be an autoimmune disease, and individuals with it frequently have other autoimmune disorders such as rheumatoid arthritis or Sjogren's syndrome. Other factors that have been associated with the development of scleroderma include family history, genetics, exposure to certain toxic substances, and chronic sickness. Scleroderma can impact people in a variety of ways. Symptoms that are common include:

  • Developing patches of hardened tightened skin, fingers, or toes that turn blue and numb in cold temperatures
  • Bloating
  • Heartburn
  • Cramping
  • Diarrhea
  • Constipation

Complications causing long-term health effects can include:

  • Loss of lung capacity
  • Heart failure
  • High blood pressure
  • Chronic digestive issues
  • Sexual dysfunction
  • Kidney disease
  • Loss of blood flow to fingers or toes, which may necessitate amputation

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