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SNP - COMT (V158M) Buccal Swab Add-On - Genova Test Kit

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The SNP - COMT (V158M) Buccal Swab Add-On - Genova Test Kit analyze specific genetic variations in the COMT (catechol-O-methyltransferase) gene using DNA obtained from buccal cells.


Test Code:




Buccal Swab


Shipping samples Monday - Thursday only is recommended to avoid shipment delays. Overnight fasting is required before collection. Patients should refrain from taking any medications or supplements until after collection. Consult with your physician prior to stopping any medications. Make sure to read and follow all collection instructions.

Test Results:

7-14 business days once the lab receives the specimen. May take longer based on weather, holiday, or lab delays.

Notice: This test can only be added to the Essential Estrogens - Hormone Test FMV (GD4209) and Essential Estrogens - Hormone Test 24-Hour (GD4210) test kits.


What is the purpose of this test?

The SNP-COMT Buccal Swab - Genova Test Kit is a genetic test that analyzes the COMT (catechol-o-methyltransferase) gene for variations. This gene is responsible for the metabolism of neurotransmitters such as dopamine, norepinephrine, and epinephrine. The test helps to identify specific genetic variations in the COMT gene that may affect an individual's ability to break down these neurotransmitters efficiently. This test is beneficial for individuals who experience symptoms of anxiety, depression, or ADHD, as these conditions may be linked to the variations in the COMT gene. By identifying these variations, healthcare providers can develop personalized treatment plans based on the individual's unique genetic makeup.


The test is simple and non-invasive, requiring only a buccal swab from the inside of the cheek. The sample is then analyzed at the Genova Diagnostics laboratory using advanced genetic testing technology. The test results are comprehensive and include detailed information about the individual's genetic variations in the COMT gene. Overall, the purpose of the Genova Diagnostics' SNP-COMT Buccal Swab - Genova Test Kit is to provide healthcare providers and individuals with valuable insights into potential health conditions that may be linked to variations in the COMT gene. By using this information, healthcare providers can develop more effective treatment plans that are tailored to the individual's specific needs.


Benefits of the SNP - COMT Buccal Swab - Genova Test Kit:

  1. Genetic Insights: By analyzing the COMT gene variant (V158M), the kit provides valuable genetic insights into an individual's neurotransmitter metabolism.
  2. Personalized Health Guidance: Knowledge of one's genetic predispositions allows for personalized health guidance, including lifestyle modifications, dietary adjustments, and targeted interventions tailored to optimize neurotransmitter function and mitigate potential health risks.
  3. Mental Health Management: Understanding genetic variations in COMT can aid in the management of mood disorders such as depression and anxiety, as well as conditions influenced by dopamine levels, such as attention deficit hyperactivity disorder (ADHD).
  4. Pain Sensitivity Assessment: The test kit provides insights into an individual's pain sensitivity, as COMT variations have been associated with differences in pain perception and response to pain management strategies.
  5. Cognitive Function Optimization: Knowledge of COMT gene variants can inform strategies to optimize cognitive function and enhance memory, attention, and executive function.

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