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Sole Allergy IgE Blood Test

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The Sole Allergy IgE Blood Test measures the IgE antibody levels in the blood to help detect a food allergy to sole fish.

Test Code: 602754

CPT Code: 86003

Also Known As:


Thermo Fisher ImmunoCAP®


No special preparation is required.

Test Results:

3-5 days. May take longer based on weather, holiday or lab delays.

Test Code: 38243

CPT Code: 86003

Also Known As:


Immunoassay (IA)


No special preparation is required.

Test Results:

4-6 days. May take longer based on weather, holiday or lab delays.


What is the purpose of this test?

Order a Sole Allergy IgE Blood Test to measure the IgE antibody levels in the blood to help detect a food allergy to sole fish. Sole is a prized food fish and is the "fish of choice" compared to other flatfish. This popular fish is typically prepared by grilling, baking, poaching, or pan-frying and is often used in soups, stews, and salads. Sole has a characteristically mild and slightly sweet flavor. The flesh is white and lean and is described as having a meaty feel due to its rigid and firm texture. With good nutritional value, sole fish is a favorite among fish lovers and enjoyed even by those who are generally not fond of fish.


Sole is low in fat and a good source of protein, B vitamins, calcium, niacin, phosphorus, and selenium. Due to its many health benefits, sole fish is the main ingredient in several seafood products. Unfortunately, many individuals with food allergies or hypersensitivity may experience an adverse reaction after consuming sole. 


What other seafood or products should I avoid if I am allergic to sole?

Individuals should also note that there is allergic cross-reactivity between various types of fish, which means that individuals with allergies to a specific finned fish are likely to have or develop an allergy to other finned fish. This cross-reactivity is due to a protein found in many fish called parvalbumin. Therefore, individuals allergic to sole fish are generally advised to avoid all finned fish, including bass, cod, herring, salmon, swordfish, snapper, and tuna.


Additionally, individuals with an allergy to swordfish should also avoid the following products:


  • Imitation fish or shellfish
  • Seafood stock (fish or shrimp)
  • Fish oil, including some omega-3 supplements
  • Seafood flavorings
  • Frozen fish sticks or patties
  • Bouillabaisse
  • Salad dressing
  • Certain meat dishes that contain seafood-based ingredients
  • Surimi (minced fish paste)
  • Worcestershire sauce and anything products that contain it, such as some barbeques sauces


What causes an allergic reaction to sole?

An allergy to sole fish triggers a reaction in an individual's immune system. This reaction is because the body views specific proteins or substances as harmful and produces IgE antibodies to combat these allergens. Unfortunately, these antibodies activate the release of histamine, which causes the symptoms of an allergic reaction.


When should I order a Sole Allergy IgE Blood Test?

Individuals may order this Sole Allergy IgE Blood Test if they have experienced symptoms related to a seafood allergy. Allergy symptoms vary depending on the individual, ranging from mild to severe reactions. The majority of food allergy symptoms occur within two hours of ingestion; however, they frequently begin within minutes. In addition, the response can be delayed by four to six hours or even longer in some rare cases.


An allergic reaction may affect the skin, intestinal lining, and air pathways. Individuals with seafood allergies may experience the following symptoms:


  • Tingling sensation near or around the mouth
  • Swelling
  • Abdominal discomfort
  • Nausea or vomiting
  • Diarrhea
  • Itching or hives
  • Congestion
  • Difficulty breathing, swallowing, or wheezing
  • Lightheadedness


An extreme, potentially life-threatening allergic reaction known as anaphylaxis may sometimes occur. An anaphylactic response requires immediate medical attention. Signs or symptoms of anaphylaxis may include:


  • Rapid or increased heart rate
  • Swollen throat or lump making it difficult to breathe
  • Low blood pressure
  • Extreme dizziness or loss of consciousness

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