What is the purpose of this test?
The Valproic Acid Blood Test, Free measures the amount of unbound or free valproic acid in the blood. Valproic acid is a prescription medication used to manage conditions such as epilepsy, bipolar disorder, and migraine prevention. Only the unbound (free) portion of the drug is biologically active and available to the body’s tissues, making this test especially important for individuals whose total drug levels may not accurately reflect the amount of medication their body can use.
This test helps doctors monitor valproic acid therapy to make sure the drug is working properly and not causing harmful side effects. Measuring the free valproic acid level can be especially important in people with low albumin levels (common in liver or kidney problems), those taking multiple medications, or anyone showing side effects of toxicity or a poor response to treatment. Regular monitoring with this therapeutic drug monitoring test ensures medication levels stay within a safe and effective range.
Who should get this test?
The Valproic Acid Blood Test, Free may be helpful for:
- Individuals currently taking valproic acid (Depakote® or Depakene®)
- Patients experiencing side effects such as nausea, tremors, confusion, or drowsiness
- People with liver or kidney disease where free drug levels may differ from total levels
- Individuals on multiple medications that may affect drug binding
- Children, elderly adults, or pregnant women on valproic acid therapy
- Patients with suspected valproic acid toxicity or overdose
- Individuals whose total valproic acid levels do not align with symptoms or seizure control
When should I order the Valproic Acid Blood Test, Free?
Individuals may consider ordering this test if they have symptoms or exposure concerns related to valproic acid medication levels.
Symptoms to consider:
- Confusion, dizziness, or unusual drowsiness
- Nausea, vomiting, or abdominal pain
- Unexplained weakness or fatigue
- Tremors or changes in movement or coordination
- Mood changes, irritability, or behavioral changes
- Difficulty controlling seizures despite medication
- Blood test results showing abnormal liver function or low albumin
If you have these symptoms or are being treated with valproic acid, the Valproic Acid Blood Test, Free, can provide useful information to help guide your doctor in adjusting your dosage and ensuring your treatment is safe and effective.
Sample ReportAlso Known As: Free Valproic Acid, Depacon®, Depakene®, Depakote®, Stavzor™, Valproate
Preparation:No special preparation required. Avoid contact of samples with plasticizers, varnishes, paint fumes, and fatty acids. The optimal collection is just prior to next dose.
Test Results:
4-6 days. May take longer based on weather, holiday or lab delays.
