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Vasoactive Intestinal Polypeptide (VIP), Plasma Test

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The Vasoactive Intestinal Polypeptide (VIP), Plasma Test measures VIP levels in the blood to aid in the diagnosis of conditions such as VIPoma, neurological disorders, and gastrointestinal disorders, as well as to evaluate treatment effectiveness.


Test Code:


CPT Code(s):



Radioimmunoassay (RIA)




Fasting is not required but is preferred. Patient must not have received radioactive substances 24 hours prior to test.

Test Results:

4-9 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

What is the purpose of this test?

A Vasoactive Intestinal Polypeptide (VIP) Plasma Test is a blood test that measures the levels of VIP in the blood. VIP is a hormone that is produced in the cells of the nervous system and digestive tract. It plays a role in various bodily functions, such as regulating blood flow, releasing digestive enzymes, and controlling the movements of the digestive tract. The test is ordered by doctors to diagnose and monitor certain medical conditions. One of them is VIPoma, a rare tumor that produces excessive amounts of VIP, leading to severe diarrhea, dehydration, and electrolyte imbalances. The test may also be used to monitor treatment response and disease progression.


Who would benefit from this test?

The Vasoactive Intestinal Polypeptide (VIP), Plasma would be beneficial to:

  • Individuals experiencing symptoms of diarrhea, abdominal pain, flushing, and sweating
  • Patients diagnosed with pancreatic islet cell tumors, pancreatic neuroendocrine tumors, or other rare disorders
  • Patients with certain endocrine disorders, such as Cushing's syndrome
  • Individuals with suspected VIPoma (a rare neuroendocrine tumor that secretes VIP)
  • Patients with suspected carcinoid syndrome (a group of symptoms caused by the release of certain hormones and other chemicals by some tumors, including VIP-secreting tumors) 
  • Patients with suspected mastocytosis (a group of rare disorders caused by the accumulation of mast cells in various organs, including the gastrointestinal tract)


When should I order a Vasoactive Intestinal Polypeptide (VIP), Plasma?

A Vasoactive Intestinal Polypeptide (VIP), Plasma test is usually ordered to help diagnose and monitor certain medical conditions. Some of the symptoms that may prompt you to order this test include:


  • Chronic diarrhea
  • Weight loss
  • Abdominal pain or cramping
  • Flushing
  • Facial swelling
  • Wheezing
  • Low blood pressure


It is important to note that these symptoms can be caused by a variety of medical conditions. Your healthcare provider will use a combination of your medical history, physical exam, and other tests to determine if a VIP test is warranted.

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