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Very Long Chain Fatty Acids Blood Test

A Very Long Chain Fatty Acids Blood Test aids in the diagnosis of Adrenoleukodystrophy (X-ALD) is a serious progressive, genetic disorder that affects the adrenal glands, the spinal cord and the white matter of the nervous system.

Sample Report

Test Code: 90559

Also Known As: Fatty Acid; VLCFA; Peroxisomal Disorders; X-ALD

Methodology: Gas Chromatography/Tandem Mass Spectrometer

Preparation: Fasting 12-14 hours before collection. Patient must not consume alcohol 24 hours before collection.

Test Results: 7-11 days. May take longer based on weather, holiday or lab delays


Very Long Chain Fatty Acids (VLCFAs), Phytanic acid, and Pristanic acid are metabolized by Peroxisomes. Defects in these pathways usually result in the accumulation in tissues and body fluids of one or more metabolites derived from the blocked metabolic steps.

This assay is used for differential diagnosis of peroxisomal disorders like:

  • Zellweger spectrum disorders of peroxisomal biogenesis
  • X-linked Adrenoleukodystrophy (X-ALD) and its adult form X-linked Adrenomyeloneuropathy (X-AMN)
  • Refsum disease (Phytanoyl-CoA hydroxylase Deficiency) & 2-methylacyl-CoA racemase deficiency


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