Complement Total (CH50) Blood Test

Complement Total (CH50) Blood Test

Quick Overview

Evaluate and follow up SLE (systemic lupus erythematosus) patient's response to therapy; may predict disease flare in SLE; evaluate for complement component deficiency; evaluate complement activity in cases of immune complex disease, glomerulonephritis, rheumatoid arthritis, SBE, cryoglobulinemia. The CH50 assay mainly evaluates the classical pathway.

Test #001941


Availability: In stock

Preparation No special preparation required.
Test Type Blood
Test Results 2-3 days. May take longer based on weather, holiday or lab delays.

The complement system is part of the body’s innate immune system. Complement proteins, numbered C1 through C9, work in sequence and together with subcomponents and inhibitors to identify and destroy foreign substances such as bacteria. In the classic complement pathway, C1 proteins (C1q, C1r and C1s) recognize microorganisms and other foreign cells, C2 through C4 proteins serve as activation mechanisms, and C5 through C9 proteins serve as attack mechanisms. The absence or deficiency of an early component protein (C1 through C4), whether inherited or acquired, can affect the body’s ability to clear an infection. A hereditary deficiency or increased consumption can result in decreased complement levels, leading to recurrent microbial infections and increased risk of developing an autoimmune disease. Complement levels may be increased during the acute-phase response to inflammation or infection.

The Complement Total, or CH50 Blood Test, assesses the overall activity of the complement system, and mainly evaluates the classic complement activation pathway. A CH50 Blood Test is often ordered to evaluate complement component deficiency and evaluate complement activity in cases of immune complex disease, glomerulonephritis (inflammation of the kidneys’ filters), rheumatoid arthritis and cryoglobulinemia (abnormal proteins in the blood that thicken in cold temperatures). It can also be used to evaluate a patient’s response to systemic lupus erythematosus (SLE) therapy and predict disease flares.

The CH50 Blood Test is also known as Complement, Total; and Total Hemolytic Complement. No fasting is required prior to the test, and results will be available within two to three days. A prior doctor’s visit is not required to order this test. Patients also do not need insurance.

See also Walk-In Lab’s C1 Inhibitor Blood Test, C1q Blood Test, C2 Blood Test and C4 Blood Test.

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