LabCorp Test

Alkaline Phosphatase Isoenzymes Blood Test

Quick Overview

Relative percentages of liver, bone, and intestinal alkaline phosphatase isoenzymes and total alkaline phosphatase.

Test #001612


Availability: In stock

Also Known As ALP Isoenzymes, Fractionated Alkaline Phosphatase, Kasahara Isoenzymes, Nag Ao Isoenzymes, Regan Isoenzymes
Preparation Fasting for 10-12 hours required.
Test Results 3-5 days. May take longer based on weather, holiday or lab delays.

Alkaline phosphatase (ALP) is present in a number of tissues including liver, bone, intestine, and placenta. The activity of ALP found in serum is a composite of isoenzymes from those sites and, in some circumstances, placental or Regan isoenzymes. Serum ALP is of interest in the diagnosis of 2 main groups of conditions-hepatobiliary disease and bone disease associated with increased osteoblastic activity.  

A rise in ALP activity occurs with all forms of cholestasis, particularly with obstructive jaundice. The response of the liver to any form of biliary tree obstruction is to synthesize more ALP. The main site of new enzyme synthesis is the hepatocytes adjacent to the biliary canaliculi.

ALP also is elevated in disorders of the skeletal system that involve osteoblast hyperactivity and bone remodeling, such as Paget's disease rickets and osteomalacia, fractures, and malignant tumors.

Moderate elevation of ALP may be seen in other disorders such as Hodgkin's disease, congestive heart failure, ulcerative colitis, regional enteritis, and intra-abdominal bacterial infections.

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