Quick Facts
- Sample: Blood
- Fasting: No special preparation is required
- Turnaround: 3-7 business days. May take longer based on weather, holiday or lab delays.
What This Test Measures
This test measures 17-hydroxyprogesterone (17-OHP), a steroid hormone produced primarily by the adrenal glands and gonads, using liquid chromatography-tandem mass spectrometry (LC-MS/MS). 17-OHP is an intermediate in the body's production of cortisol and other steroid hormones.
17-OHP testing is commonly used when evaluating congenital adrenal hyperplasia (CAH), particularly CAH caused by 21-hydroxylase deficiency. When this enzyme is deficient, 17-OHP can accumulate and may be present at markedly elevated levels.
The test may also provide useful information when evaluating symptoms associated with excess androgen production, such as hirsutism or menstrual irregularities, and may be considered during evaluations for infertility or certain adrenal or ovarian disorders.
This is a single-analyte test that measures 17-hydroxyprogesterone and does not include other adrenal or reproductive hormones.
Benefits
- Measures 17-hydroxyprogesterone using LC-MS/MS methodology
- Helps evaluate for congenital adrenal hyperplasia (CAH)
- May be used to help monitor individuals with certain forms of CAH
- Supports evaluation of excess androgen-related symptoms
- May provide useful information during evaluation of infertility or certain adrenal or ovarian disorders
Who Is This Test For?
- Individuals undergoing evaluation for congenital adrenal hyperplasia (CAH)
- Individuals with suspected nonclassic or late-onset CAH
- Individuals with symptoms of androgen excess, such as hirsutism or menstrual irregularities
- Individuals undergoing evaluation for unexplained infertility
- Individuals with suspected adrenal or ovarian hormone abnormalities
- Individuals with CAH whose healthcare provider is monitoring treatment
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What does the 17-Hydroxyprogesterone Blood Test measure?
This test measures 17-hydroxyprogesterone (17-OHP), a steroid hormone involved in the pathway the body uses to produce cortisol and other steroid hormones. Although its name includes "progesterone," 17-OHP is a distinct steroid hormone and should not be confused with a standard progesterone blood test.
2. Why is 17-OHP tested for congenital adrenal hyperplasia?
17-OHP can become markedly elevated in congenital adrenal hyperplasia (CAH), particularly when CAH is caused by 21-hydroxylase deficiency. Measuring 17-OHP can therefore provide important information when evaluating for this condition.
3. Can this test help evaluate nonclassic or late-onset CAH?
Yes. 17-OHP testing may be used when nonclassic CAH is suspected in older children or adults. Symptoms can include excess hair growth, menstrual irregularities, signs of androgen excess, or infertility. Additional testing may be necessary to confirm or rule out CAH.
4. Can this test diagnose PCOS?
No. A 17-OHP result does not diagnose polycystic ovary syndrome (PCOS). Because symptoms of nonclassic CAH can overlap with symptoms seen in PCOS, 17-OHP may be measured as part of an evaluation to help distinguish between possible causes of androgen-related symptoms.
5. Can 17-OHP be used to monitor CAH treatment?
Yes. In individuals diagnosed with certain forms of CAH, 17-OHP may be measured along with clinical findings and other laboratory tests to help assess treatment. Testing schedules and treatment goals should be determined by a healthcare provider.
6. How often should I get tested?
There is no universal testing schedule. Testing frequency depends on the reason for testing and, for individuals being treated for CAH, the monitoring plan established by their healthcare provider.
7. Do I need to fast before this test?
No special preparation is required.
8. How do I interpret my results?
17-OHP results should be interpreted using the reference interval provided by the laboratory that performed the test. Expected levels vary according to factors such as age and sex.
Elevated 17-OHP may occur with certain forms of congenital adrenal hyperplasia, but an abnormal result does not establish a diagnosis on its own. Your healthcare provider can interpret the result alongside your symptoms, medical history, and other laboratory findings.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
9. What should I do if my results are abnormal?
Review abnormal results with a qualified healthcare provider. Depending on the reason for testing, additional hormone testing or other evaluation may be appropriate.
Pre-test Preparation
No special preparation is required.
