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Alkaline Phosphatase Isoenzymes Blood Test

The alkaline phosphatase isoenzymes blood test measures the amounts of different types of alkaline phosphatase in the blood.


Test Code: 001612

CPT Code: 84075,84080

Also Known As: ALP Isoenzymes, Fractionated Alkaline Phosphatase, Kasahara Isoenzymes, Nag Ao Isoenzymes, Regan Isoenzymes

Methodology:

Electrophoresis

Specimen Type: Serum

Preparation:

Fasting for 10-12 hours required.

Test Results:

3-5 days. May take longer based on weather, holiday or lab delays.


Details:

Test includes: Relative percentages of liver, bone, and intestinal alkaline phosphatase isoenzymes and total alkaline phosphatase


Test Code: 231

CPT Code: 84075,84080

Also Known As: ALP Isoenzymes, Fractionated Alkaline Phosphatase, Kasahara Isoenzymes, Nag Ao Isoenzymes, Regan Isoenzymes

Methodology:

Electrophoresis • Spectrophotometry (SP)

Specimen Type: Serum

Preparation:

Fasting for 10-12 hours required.

Test Results:

5-8 days. May take longer based on weather, holiday or lab delays.


Details:

Test includes: Alkaline Phosphatase, Intestinal Isoenzymes, Bone Isoenzymes, Liver Isoenzymes, Placental Isoenzymes, Macrohepatic Isoenzymes

Description

The ALP isoenzyme test, also referred to as ALK phos isoenzyme test, will assist in determining the part of the body that is the cause of elevated alkaline phosphatase (ALP).  This test is most commonly used to test alkaline phosphatase made in the bones and liver tissues and will indicate whether the elevation is in the bone ALP or liver ALP.  In addition, it can be used in diagnosing and monitoring:

  • pain the abdomen
  • bone disease
  • parathyroid gland disease
  • liver, gallbladder, or bile duct disease
  • vitamin D deficiency
  • medications that may affect the liver

High alkaline phosphatase levels may suggest:

  • bone disease
  • biliary obstruction
  • eating a fatty meal if you have blood type O or B
  • hepatitis
  • healing fracture
  • hyperparathyroidism
  • liver disease
  • leukemia
  • lymphoma
  • osteomalacia
  • osteoblastic bone tumors
  • rickets
  • Paget’s disease
  • sarcoidosis

Lower than normal levels of alkaline phosphatase can be caused by:

  • hypophosphatasia
  • protein deficiency
  • malnutrition
  • Wilson’s disease

Levels that are minimally elevated may not be a problem unless there are other signs of a medical problem or disease.

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