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Antineutrophil Cytoplasmic Antibodies (ANCA) Blood Test

The ANCA blood test is used to detect Antineutrophil cytoplasmic autoantibodies which (ANCA) are a serological marker associated with vasculitis and glomerulonephritis.

Sample Report

Test Code: 162388

Also Known As: ANCA; Antineutrophil Cytoplasmic Antibody; pANCA; cANCA

Methodology: Indirect fluorescent antibody (IFA)

Preparation: No special preparation required.

Test Results: 1-2 days. May take longer based on weather, holiday or lab delays.

Description

Specifically, ANCA has been found in patients with active Wegener granulomatosis, microscopic polyarteritis nodosa, and idiopathic crescentic glomerulonephritis (with manifestations ranging from kidney-limited disease to extrarenal systemic disease, including pulmonary-renal syndromes). Glomerular lesions in patients with ANCA-associated systemic vasculitis or renal-limited disease are virtually identical. Normal controls are negative for ANCA, and <10% of patients with other renal diseases are positive. ANCA may be directly involved in the vascular injury's pathogenesis that causes the clinical manifestations in ANCA-associated disease. 

Antineutrophil cytoplasmic autoantibodies exhibiting pANCA or cANCA patterns are detected using indirect immunofluorescent antibody (IFA) techniques with a substrate of ethanol-fixed human neutrophils. Positive patient sera with perinuclear or nuclear patterns are repeated using a formalin-fixed substrate in order to differentiate the presence of true pANCA antibodies from possible interference with antinuclear antibodies (ANA).

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