Complement Total (CH50) Blood Test
The Complement Total (CH50) Blood Test monitors and diagnoses autoimmune disorders by measuring total complement levels in the blood.
What is the purpose of this test?
Order this Complement Total (CH50) Blood Test, which monitors and diagnoses autoimmune disorders by measuring total complement levels in the blood. The complement system is a collection of around 60 proteins that exist in blood plasma or on the surface of certain cells. These proteins work in conjunction with the immune system and play a crucial role in safeguarding the body against infections, as well as removing dead cells and foreign material. Some individuals may have a deficiency in certain complement proteins, which makes them susceptible to particular infections or autoimmune disorders. The nine major complement proteins are designated as C1 through C9, and their total activity can be measured using the CH50 Blood Test.
A complement total test may be used to:
- Diagnose the underlying cause of recurrent microbial infections, angioedema, or inflammation.
- Diagnose and monitor individuals with autoimmune disorders like lupus or rheumatoid arthritis.
- Monitor diseases and conditions that arise from immune complexes, such as kidney disorders and vasculitis.
What conditions are associated with abnormal complement activity?
Complement activity levels can differ depending on the specific location in the body. Increased complement activity may be seen in the following:
- Certain infections
- Ulcerative colitis
Decreased complement activity may be seen in the following:
- Hereditary angioedema
- Kidney transplant rejection
- Lupus nephritis
- Systemic lupus erythematosus
- Rare inherited complement deficiencies
When should I order a Complement Total (CH50) Blood Test?
Individuals may order this test if they have experienced symptoms related to an autoimmune disorder. Common signs or symptoms of an autoimmune disorder include:
- Chronic joint pain or swelling
- Recurring fever
- Abdominal pain or gastrointestinal problems
- Swollen glands
- Skin rashes
- Nausea or vomiting
- Dizziness or lightheadedness
- Dry eye or blurred vision
- Sudden weight loss
- Thirst and frequent urination
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