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Beta 2 Microglobulin Serum Test

A Beta 2 Microglobulin Serum Test evaluates the severity and prognosis of multiple myeloma, chronic lymphocytic leukemia, or non-Hodgkin's lymphoma; detect kidney damage and distinguish between glomerular and tubular kidney disorders.

Sample Report

Test Code: 010181

Also Known As: B2 Microglobulin, B2M Serum, Beta Microglobulin, Beta-2-Microglobulin, Microglobulin, Beta 2, Beta 2 Microglobulin, Thymotaxin

Methodology: Immunochemiluminometric assay (ICMA)

Preparation: No special preparation required.

Test Results: 1-2 days. May take longer based on weather, holiday or lab delays.


The beta-2 microglobulin (B2M) blood test is used to help detect kidney damage and follow kidney disorders, to help evaluate the severity and prognosis of certain cancers such as multiple myeloma and some lymphomas, and it is sometimes used to monitor people who are exposed to cadmium. 

This test may be used when known physical or suspected kidney damage occurs to distinguish between glomerular and tubular disorders of the kidney. Increased levels of B2M in the blood indicate that there is a problem, but they are not diagnostic of a specific disease or condition. 

The B2M test may be ordered when a person has the following symptoms associated with kidney dysfunction: 

  • Swelling or puffiness around the eyes or in the face, ankles or wrists 
  • Protein in the urine or urine that is foamy or bloody
  • Weakness or fatigue
  • Nausea 

This test also may be ordered during the initial workup of a person who has been diagnosed with multiple myeloma in order to stage the disease and periodically to evaluate disease activity and monitor the effectiveness of treatment. It may sometimes be ordered when a person has myeloma or lymphoma to help determine their likely prognosis.


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