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CICA: Celiac, IBS, and Crohn's Genetic Only - ALCAT Test Kit

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The CICA: Celiac, IBS, and Crohn's Genetic Only - ALCAT Test Kit assesses your genetic predisposition to celiac and Crohn's disease and evaluates GI function. Note: This is a pre-paid shipping test kit that will be mailed and it requires a blood draw. Please Click Here to locate a lab for specimen collection.


Test Code:



HLA: Enzyme immunoassay (EIA), DPG: ELISA, TTG: ELISA




No fasting is required. Patients should avoid consuming antibiotics and antihistamines for 5 days, oral steroids for 7 days, and topical steroids for 24 hours before collection. Patients should also reduce vitamin C to 2500 mg or less for 48 hours before collection. If possible, take medications or supplements after collection. Check with your physician before stopping any medications. Make sure to read all collection instructions.

Test Results:

7-10 business days once the lab receives the specimen. May take longer based on weather, holiday, or lab delays.


Panel includes:  Genetic: HLA typing for celiac disease: HLA-DQ2.5 and HLA-DQ8; Genetic Markers for Crohn's: ATG16L1 and NOD2

The CICA: Celiac, IBS, and Crohn's Genetic Only - ALCAT Test Kit includes:

  • HLA typing for celiac disease
  • Genetic biomarkers for Crohn’s disease


What is the purpose of this test?

Order this CICA: Celiac, IBS, and Crohn's Genetic Only - ALCAT Test Kit, which assesses your genetic predisposition to celiac and Crohn's disease, while also evaluating serum markers for active disease. Its purpose is to evaluate gastrointestinal function.


The CICA test uses a single blood draw to analyze genetic predisposition. It can determine the risk of celiac disease by examining the presence or absence of the HLA-DQ genotypes, specifically testing for both the DQ8 and DQ2.5 genotypes. The DQ2.5 genotype is associated with a higher risk of celiac disease. Additionally, the test looks for genetic markers and mutations in the ATG16L1 and NOD2 genes associated with Crohn's disease.


Prevalence of GI issues in the U.S.

Did you know that in the United States, approximately 60-70 million individuals suffer from gastrointestinal disorders? It's interesting to note that celiac disease might be present even if there are no GI symptoms, especially among family members of those with celiac disease.


  • In the United States, 40% of Americans suffer from G.I. disorders.
  • Ulcerative colitis affects up to 20% of adults in North America.
  • It is estimated that around 1% of the general population experiences symptoms of celiac disease.
  • Indigestion and constipation are experienced by 15% of individuals in Western countries.


It's not surprising that there is some overlap between these disorders.


Who can benefit from the CICA: Celiac, IBS, and Crohn's Genetic Only - ALCAT Test Kit?


  • Individuals experiencing gastrointestinal symptoms and autoimmune disorders that may indicate a gluten-related issue.
  • Individuals who have experienced increased intestinal permeability may be at a higher risk for autoimmune disorders and other related conditions.
  • Individuals suspected of having Crohn's or celiac disease.
  • Individuals experiencing symptoms of IBS, such as diarrhea, bloating, or cramping.
  • Individuals with chronic fatigue.
  • Individuals who have nutrient malabsorption or deficiency.
  • Individuals experiencing unexplained symptoms such as unintentional weight loss or skin rashes.

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