What is the purpose of this test?
The Cortisol: Cortisone Ratio Profile Blood Test measures the balance between two important adrenal hormones: cortisol and cortisone. Cortisol is an active hormone released by the adrenal glands in response to stress, while cortisone is its inactive form. The body regularly converts cortisol to cortisone and vice versa through specific enzymes. This balance helps regulate your body’s response to stress, inflammation, immune function, and metabolism. By evaluating this ratio, the test can provide insights into how well your adrenal system is functioning and whether it’s producing or converting these hormones properly.
Abnormal cortisol to cortisone ratios may indicate adrenal gland dysfunction, enzyme imbalances, or chronic stress. A high ratio may suggest increased active cortisol levels, which can contribute to symptoms like anxiety, insomnia, or high blood pressure. A low ratio may indicate reduced cortisol activity, potentially linked to fatigue, inflammation, or adrenal fatigue. This test is particularly useful in assessing adrenal health, identifying possible enzyme deficiencies, and guiding treatment in individuals with suspected hormone imbalances or chronic stress-related conditions.
Who should get this test?
The Cortisol: Cortisone Ratio Profile Blood Test may benefit:
- Individuals with symptoms of adrenal fatigue or burnout
- Those experiencing unexplained chronic stress, anxiety, or mood swings
- People with persistent fatigue or low energy despite adequate sleep
- Patients being monitored for Cushing’s syndrome or Addison’s disease
- Individuals with autoimmune conditions or hormonal imbalances
- Those undergoing functional medicine evaluations for metabolic issues
- People who suspect abnormal cortisol levels but want a more complete picture
When should I order the Cortisol: Cortisone Ratio Profile Blood Test?
Individuals may consider ordering this test if they have symptoms or exposure concerns related to adrenal hormone imbalance.
Symptoms to consider:
- Fatigue that doesn’t improve with rest
- Difficulty managing stress or feeling overwhelmed easily
- Trouble sleeping, especially waking up tired
- Cravings for salty foods or dizziness when standing up quickly
- Weight gain, especially around the midsection
- Muscle weakness or low stamina
- Frequent illness or low immune function
If you have these symptoms or suspect a cortisol imbalance, the Cortisol: Cortisone Ratio Profile Blood Test can help guide you and your healthcare provider in identifying hormone-related concerns and creating an appropriate wellness plan.
Preparation:No special preparation required.
Test Results:
5-12 days. May take longer based on weather, holiday or lab delays.
