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Methylation Profile Plasma - Doctor's Data Test Kit

Methylation is a process by which a gene's behavior is altered, but the gene itself isn't changed. It requires Vitamin B12 and Folic Acid to convert nutrients from food to energy. If the process is blocked, through stress, viruses, toxins, etc., Glutathione cannot be created. Glutathione detoxifies the body, among other body processes. Note: This is a pre-paid shipping test kit that will be mailed and it requires a blood draw. Please Click Here to locate a lab for specimen collection.

Sample Report

Test Code: DDMP

Also Known As:


Specimen Type: Plasma


10-12 hours fasting is required. 48 hours prior to the specimen collection discontinue taking dietary supplements containing methionine, cysteine, and SAMe. Check with physician before stopping medications. Specimen must be sent to lab by overnight mail Monday-Thursday only. Please read patient instructions very carefully prior to beginning the test.

Test Results:

7-10 days once the lab receives the specimen. May take longer based on weather, holiday or lab delays.


Normal methionine metabolism is absolutely critical for folate-dependent transmethylation and transsulfuration. Abnormal metabolism of methionine can be found in both genders at any age. It is usually associated with genetic or nutritional deficiencies, aging and exposures to environmental toxins. For example, lead can impair methylation via inhibition of the enzyme methyltetrahydrofolate reductase (MTHFR). 

Conditions associated with untreated, aberrant methionine metabolism include, but are not limited to:

  • Abnormal neurotransmitter metabolism and psychiatric disorders such as schizophrenia and bipolar disorder
  • Neurodegenerative diseases
  • Autism
  • Dysregulation of nitric acid homeostasis
  • Oxidative stress
  • Global under-methylation, synthesis and repair of DNA
  • Immune dysregulation/autoimmunity
  • Cancer
  • Cardiovascular disease
  • Congenital heart disease and birth defects
  • Impaired endogenous detoxification processes
  • Increased risk for Down syndrome.

This profile evaluates the plasma levels of methionine, cysteine, SAM, SAH, Hcy and cystathionine, and provides the important "methylation index," a ratio of SAM to SAH. The test results can appropriately guide nutritional support to improve or normalize methionine metabolism and meliorate or prevent the potential adverse consequences associated with inadequate methylation and transsulfuration capacity.

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