Quick Facts
- Sample: Blood
- Fasting: No fasting required. Stop biotin consumption at least 72 hours prior to collection.
- Turnaround: 2-3 days. May take longer based on weather, holiday, or lab delays.
What This Test Measures
This test measures dehydroepiandrosterone sulfate (DHEA-S) in the blood, a circulating androgen produced mainly by the adrenal cortex, with smaller amounts made in the testes and ovaries. DHEA-S can be converted into more potent androgens such as testosterone and androstenedione, or into estrogen, which makes it a hormone precursor rather than the active end hormone itself.
Because the adrenal glands are the primary source of DHEA-S, this measurement serves as a marker of adrenal function. It reflects circulating DHEA-S levels directly and does not evaluate testosterone, estrogen, or other downstream hormones on its own.
Benefits
- Helps evaluate whether the adrenal glands are functioning properly.
- Aids in identifying the source of excess androgen production.
- Supports differentiating adrenal from ovarian or testicular origins.
- Assists in evaluating possible adrenal cortex tumors.
- Helps assess for adrenogenital syndrome or adrenal hyperplasia.
Who Is This Test For?
- Individuals experiencing signs of virilization, such as excess facial or body hair.
- Women with irregular or absent menstrual periods.
- Individuals with infertility that is linked to possible excess androgen production.
- People with symptoms suggesting adrenal gland dysfunction.
- Those whose healthcare provider wants to evaluate adrenal function.
- Individuals with symptoms associated with adrenogenital syndrome or adrenal hyperplasia.
How It Works
- Order Your Test Online
- Visit a Local Lab
- Get Results Online
FAQ
1. What is the purpose of this hormone test?
This test measures DHEA-S, an androgen precursor produced primarily by the adrenal cortex. It can help a healthcare provider evaluate adrenal gland function and investigate the source of excess androgen production associated with conditions such as virilization, hirsutism, infertility, or amenorrhea. This test does not diagnose any condition on its own, and results are typically reviewed alongside symptoms and other clinical information.
2. Who would benefit from this test?
This test may be useful for individuals experiencing symptoms of excess androgen production, such as irregular menstrual periods, excess facial or body hair, or infertility. It may also be appropriate for those whose healthcare provider wants to assess adrenal gland function or investigate signs of adrenal gland conditions like hyperplasia or adrenogenital syndrome.
3. When should I order this test?
You may consider this test if you are experiencing symptoms related to excess male hormone activity, or if a healthcare provider wants to evaluate adrenal gland function as part of a broader assessment. This test does not replace a full medical evaluation and is best considered alongside a discussion of your symptoms and history with a healthcare provider.
4. How does this test differ from other hormone tests?
This test measures DHEA-S specifically, a precursor androgen made largely by the adrenal glands, rather than active hormones like testosterone or estrogen that DHEA-S can be converted into. Because DHEA-S is a precursor, it does not provide the same information as a direct measurement of testosterone or estrogen, and results reflect adrenal androgen output rather than downstream hormone activity.
5. Do I need to fast before this test?
No fasting is required for this test. You should stop biotin consumption at least 72 hours prior to your blood collection to avoid interference with results.
6. How quickly will I get results?
Results are typically available in 2-3 days. Turnaround time may take longer based on weather, holidays, or lab delays.
7. How do I interpret the results?
DHEA-S results are best interpreted in the context of your symptoms, medical history, sex, age, and any medications or supplements you take. Because DHEA-S is a precursor hormone, results are often reviewed alongside other clinical findings rather than in isolation. An abnormal result does not automatically confirm a hormonal condition, and a normal result does not rule one out.
Disclaimer: Reference ranges may vary by laboratory. Listed ranges are general guidelines and may differ from those used by the performing lab. Always consult your healthcare provider for interpretation.
8. What should I do if my results are abnormal?
If your results fall outside the expected range, review them with a qualified healthcare provider. They can help determine whether additional evaluation or testing is appropriate based on your symptoms and overall health. This test result alone does not provide a complete clinical picture.
9. How often should I get tested?
Testing frequency should be determined as directed by your healthcare provider, based on your individual symptoms and health history. There is no standard repeat testing schedule associated with this test.
Pre-test preparation
No fasting is required. Stop biotin consumption at least 72 hours prior to the collection.
