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Hemoglobinopathy Evaluation Blood Test

A hemoglobinopathy fractionation blood test diagnoses thalassemias and hemoglobin variants.

Sample Report

Test Code: 35489

Also Known As: Hemoglobin Electrophoresis,HGB Variants,HB S,Hemoglobin F,HGB Evaluation,Hemoglobin S,HB A2,HGB Electrophoresis,Hemoglobin Variants,Hemoglobin A2,Thalassemia Screen,HB F

Methodology: Electronic Sizing and Counting/Cytometry • High Performance Liquid Chromatography (HPLC) followed by, if necessary, Electrophoresis

Preparation: No special preparation required.

Test Results: 4-6 days. May take longer based on weather, holiday or lab delays.


The Hemoglobinopathy Evaluation Profile Blood Test, or Hemoglobin Fractionation, aids in the diagnosis of hemoglobinopathy, an inherited blood disorder characterized by the presence of an abnormal form of hemoglobin (known as a variant) or decreased hemoglobin production (known as thalassemia).

Hemoglobin (Hb) is a protein found in red blood cells (RBCs) that binds to oxygen and helps transport it throughout the body. The shape, size, and function of RBCs may be altered when hemoglobin variants are present, which could result in inefficient oxygen transportation and premature destruction of the cells, leading to hemolytic anemia. Symptoms of hemolytic anemia include weakness, fatigue, jaundice and pale skin. Severe hemoglobinopathies, such as homozygous Hb S (Sickle Cell Anemia), can result in symptoms such as episodes of acute pain, shortness of breath and an enlarged spleen.

This test includes Hemoglobin A1, Fetal Hemoglobin, Hemoglobin A2 and any hemoglobin variants, Red Blood Cell Count, Hemoglobin, Hematocrit, MCV, MCH, RDW.


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