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Hemoglobinopathy Evaluation Blood Test

A hemoglobinopathy evaluation blood test diagnoses thalassemias and hemoglobin variants.


Test Code: 121690

Also Known As: Hemoglobinopathy Fractionation Cascade, Hemoglobin Electrophoresis, HGB Variants, HB S, Hemoglobin F, HGB Evaluation, Hemoglobin S, HB A2, HGB Electrophoresis, Hemoglobin Variants, Hemoglobin A2,Thalassemia Screen, HB F

Methodology:

Capillary Electrophoresis (CE) • High-Pressure Liquid Chromatography (HPLC) • Hgb Solubility: Sodium Hydrosulfite Reduction

Preparation:

No special preparation required.

Test Results:

2-5 days. May take longer based on weather, holiday or lab delays.


Details:

This test includes Hemoglobin F, Hemoglobin A, Hemoglobin A2, and Hemoglobin S. If abnormal hemoglobin is detected, appropriate testing will be performed. Depending on findings, one or more reflexive tests may be required to provide a clinical interpretation. These tests may include High-Pressure Liquid Chromatography (HPLC) and/or hemoglobin solubility testing.

Sample Report

Test Code: 35489

CPT Code: 83020, 85014, 85018, 85041

Also Known As: Hemoglobinopathy Fractionation Cascade, Hemoglobin Electrophoresis, HGB Variants, HB S, Hemoglobin F, HGB Evaluation, Hemoglobin S, HB A2, HGB Electrophoresis, Hemoglobin Variants, Hemoglobin A2,Thalassemia Screen, HB F

Methodology:

Electronic Sizing and Counting/Cytometry • High-Performance Liquid Chromatography (HPLC) followed by, if necessary, Electrophoresis

Preparation:

No special preparation required.

Test Results:

4-6 days. May take longer based on weather, holiday or lab delays.


Details:

This test includes Fetal Hemoglobin, Hematocrit, Hemoglobin, Hemoglobin A1, Hemoglobin A2, and any Hemoglobin variants, MCH, MCV, RDW, and Red Blood Cell Count. Depending on findings, a reflexive test may be required to provide a clinical interpretation. This test may include High-Performance Liquid Chromatography (HPLC).

Description

This test measures hemoglobin levels and looks for abnormal types of hemoglobin. This test also aids in diagnosing anemia, sickle cell disease, and other hemoglobin disorders (known as Hemoglobinopathy). Hemoglobinopathy is an inherited blood disorder characterized by an abnormal form of hemoglobin (variant) or decreased hemoglobin production (Thalassemia).

Hemoglobin (Hgb) is a protein found in your red blood cells that transfers oxygen from your lungs to the rest of your body. There are several different types of hemoglobin, such as Hgb A, Hgb F, Hgb S, Hgb C, and Hgb E. An abnormal level of certain hemoglobins in the red blood cells may alter their shape, size, and function. This alteration may cause inefficient oxygen flow and premature destruction of the cells, known as hemolytic anemia. Symptoms of hemolytic anemia include:

  • weakness
  • fatigue
  • jaundice
  • pale skin

Another abnormal type of hemoglobin is Hgb S, which causes Sickle Cell Anemia. Sickle cell anemia is an inherited disease that causes the body to create inflexible, "sickle" shaped red blood cells. Red blood cells should be flexible to flow easily through blood vessels; however, sickle cells can get stuck in the blood vessels. Patients with abnormal levels of Hgb S or Sickle cell anemia may experience symptoms such as:

  • severe or chronic pain
  • shortness of breath
  • enlarged spleen
  • infections

 

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