Immunofixation (IFE) Serum Test
The Immunofixation (IFE) Serum Test identifies monoclonal immunoglobulin gammopathies, which may indicate multiple myeloma or Waldenstrom's macroglobulinemia.
Description
What is the purpose of this test?
The Immunofixation (IFE) Serum Test detects and identifies monoclonal immunoglobulin gammopathies, which could indicate conditions like multiple myeloma or Waldenstrom's macroglobulinemia. It detects immunoglobulins in the blood and can be ordered to evaluate a monoclonal globulin detected in a protein electrophoresis or to delineate a possible lymphoproliferative process. The IFE test characterizes the specific heavy and light chain components of a monoclonal protein. This test alone cannot be used to make a diagnosis, but only indicates whether abnormal Ig is present.
When should I order an Immunofixation (IFE) Serum Test?
Individuals may order this test if they have experienced symptoms related to multiple myeloma or Waldenstrom's macroglobulinemia. Common signs or symptoms of multiple myeloma may include:
- Bone pain in the back or ribs
- Weakness and fatigue
- Weight loss
- Broken bones
- Recurrent infections
- Weakness in the legs
- Nausea/vomiting
Additionally, symptoms of Waldenstrom's macroglobulinemia may include:
- Weakness
- Severe fatigue
- Bleeding from the nose or gums
- Weight loss
- Bruises or other skin lesions
- Blurred vision
- Swelling of the lymph nodes, spleen, or liver
