Immunofixation (IFE) Serum Test

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The Immunofixation (IFE) Serum Test identifies monoclonal immunoglobulin gammopathies, which may indicate multiple myeloma or Waldenstrom's macroglobulinemia.

LabCorp

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Test Code:

001685

CPT Code(s):

82784(x3),86334

Also Known As:

Electrophoresis, Serum, IFE, IEP, Serum, IFE, Serum, Immunoelectrophoresis, Serum, Immunofixation, Serum IEP, Serum Immunoelectrophoresis, Serum Immunofixation, IFX

Methodology:

Electrophoresis followed by immunodiffusion against monospecific antisera to immunoglobulin and individual heavy and light chains (IFE); turbidimetric quantitation of IgA, IgG, and IgM

Specimen:

Blood

Preparation:

Fasting for at least 10-12 hours is required.

Test Results:

2-3 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling LabCorp tests to residents in the following states:NY, NJ, RI, MA, MD

Quest

Sample Report Compare

Test Code:

549

CPT Code(s):

86334

Also Known As:

Electrophoresis, Serum, IFE, IEP, Serum, IFE, Serum, Immunoelectrophoresis, Serum, Immunofixation, Serum IEP, Serum Immunoelectrophoresis, Serum Immunofixation, IFX

Methodology:

Immunofixation

Specimen:

Blood

Preparation:

Fasting for at least 10-12 hours is required.

Test Results:

2-3 days. May take longer based on weather, holiday, or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

What is the purpose of this test?

The Immunofixation (IFE) Serum Test detects and identifies monoclonal immunoglobulin gammopathies, which could indicate conditions like multiple myeloma or Waldenstrom's macroglobulinemia. It detects immunoglobulins in the blood and can be ordered to evaluate a monoclonal globulin detected in a protein electrophoresis or to delineate a possible lymphoproliferative process. The IFE test characterizes the specific heavy and light chain components of a monoclonal protein. This test alone cannot be used to make a diagnosis, but only indicates whether abnormal Ig is present.

When should I order an Immunofixation (IFE) Serum Test?

Individuals may order this test if they have experienced symptoms related to multiple myeloma or Waldenstrom's macroglobulinemia. Common signs or symptoms of multiple myeloma may include:

Bone pain in the back or ribs
Weakness and fatigue
Weight loss
Broken bones
Recurrent infections
Weakness in the legs
Nausea/vomiting

Additionally, symptoms of Waldenstrom's macroglobulinemia may include:

Weakness
Severe fatigue
Bleeding from the nose or gums
Weight loss
Bruises or other skin lesions
Blurred vision
Swelling of the lymph nodes, spleen, or liver

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