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Insulin-like Growth Factor-binding Protein 3 (IGFBP-3) Blood Test

An IGFBP-3 Blood Test is used to measure this protein which is the major carrier of IGFs in plasma.

Sample Report

Test Code: 140152

CPT Code: 83520

Also Known As: IGFBP-3

Methodology: Immunochemiluminometric assay (ICMA)

Specimen Type: Blood

Preparation: No special preparation required.

Test Results: 3-4 days. May take longer based on weather, holiday or lab delays.


Test Code: 34458

CPT Code: 83520

Also Known As: IGFBP-3

Methodology: Immunoassay (IA)

Specimen Type: Blood

Preparation: No special preparation required.

Test Results: 3-4 days. May take longer based on weather, holiday or lab delays.

Description

Approximately 95% of the IGF-I and IGF-II are bound to IGFBP-3, which makes this protein the major carrier of IGFs in plasma. One of the principal functions of binding proteins is to extend the half-life of the IGFs from eight minutes to several hours. In this way, IGFBP-3 acts as a stabilizer, providing a constant level of IGF. The serum level of IGFBP-3 appears to be a constant over 24 hours and the protein was found to be growth hormone (GH) dependent, which makes the detection of IGFBP-3 very useful in the evaluation of growth hormone secretion. Single IGFBP-3 measurements correlate significantly with the logarithm of the integrated spontaneous GH secretions.

Advantages of IGFBP-3 over IGF-1 are the higher levels in young children which gives a better discrimination between normal and subnormal levels. The IGFBP-3 assay is also used to diagnose children with short stature having normal GH levels. Some children with short stature give subnormal IGF-I levels despite normal GH levels. IGFBP-3 was found to be a more reliable parameter for monitoring the efficacy of therapy; therefore, it is a useful adjunct to the measurement of IGF-I.

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