Iron and Total Iron-Binding Capacity (TIBC) Blood Test
An Iron and Total Iron-Binding Capacity (TIBC) Blood Test is used to test for the differential diagnosis of anemia, especially with hypochromia and/or low MCV.
The Iron and TIBC Blood Test is ordered to assess the body's ability to bind and transport iron in the blood. It is used when iron deficiency or iron overload is suspected.
The Iron and TIBC Blood Test goes by many names: TIBC and Iron, TIBC and Fe, Fe and TIBC, Iron Indices, Iron Profile, Transferrin Saturation, TIBC (Total Iron-Binding Capacity), and UIBC (Unsaturated Iron-Binding Capacity).
The Iron and TIBC Blood Test quantifies iron serum and total iron-binding capacity (TIBC). Iron serum measures iron levels in the blood, while TIBC measures the total amount of iron that transferrin can bind (transferrin is the primary protein that binds to iron and transports it throughout the body). These quantities are used to calculate transferrin saturation, an indicator of the body’s iron status. In iron deficiency states, iron levels are low while the TIBC is higher, resulting in low transferrin saturation. In iron overload states, iron levels are high while the TIBC is low or normal, resulting in an increased transferrin saturation. This test may be ordered along with other iron-related tests such as a Ferritin Serum Test.
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