Liver-Kidney Microsomal (LKM) Antibodies Serum Test

What is the purpose of this test?

Order this Liver-Kidney Microsomal (LKM) Antibodies Serum Test, which detects LKM antibodies in the blood to screen for autoimmune hepatitis. Liver kidney microsomal (Anti-LKM-1) antibodies are autoantibodies that target CYP2D6, a protein found primarily in liver cells, and are strongly associated with type 2 autoimmune hepatitis. This condition is an acute or chronic liver inflammation that can lead to liver cirrhosis and failure. There are two main types of autoimmune hepatitis, type 1 being the most common in the United States and associated with SMA. In contrast, type 2 is less common, more severe, and associated with anti-LKM-1 antibodies, primarily affecting young girls and more common in Europe.

The LKM antibodies test is often used in conjunction with an SMA and ANA test to diagnose autoimmune hepatitis and differentiate between type 1 and type 2. It can also monitor abnormal liver test results, such as persistently elevated ALT, AST, or bilirubin. Additional tests, like immunoglobulins, may be ordered to rule out viral hepatitis and determine if autoimmune hepatitis or hepatitis B/C is present.

When should I order an LKM Antibodies Serum Test?

Individuals may order this test if they have experienced symptoms related to autoimmune hepatitis. Common signs or symptoms of this condition include:

• Itchiness
• An enlarged liver
• Joint pain
• Abdominal pain or bloating
• Abnormal blood vessels in the skin
• Nausea or vomiting
• Dark colored urine
• Loss of appetite
• Pale colored stools
• Muscle pain
• Lack of menstrual periods
• Skin rashes
• Edema