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Metanephrines, Fractionated Urine Test, 24-Hour

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The metanephrines, fractionated urine test is used to measure the amount of metanephrines in your urine made over a 24-hour period.


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Test Code:


CPT Code(s):



Liquid chromatography/tandem mass spectrometry (LC/MS-MS)




You must take your lab order to the lab to obtain a proper specimen container before collection. It is preferable for the patient to be off medications for three days prior to collection. Patient should avoid tobacco, tea, coffee for three days prior to specimen collection. Common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha, and beta-blockers) cause minimal or no interference. Medications that are alpha agonists (Aldomet), alpha-blockers (Dibenzyline) should be avoided 18-24 hours prior to specimen collection. Check with physician before stopping medications.

Test Results:

8-10 days. May take longer based on weather, holiday or lab delays.

Walk-In Lab is prohibited from selling Quest tests to residents in the following states:AZ, NY, NJ, RI

Metanephrines, 24-Hour Urine

When you're physically or emotionally stressed, your body releases catecholamines. These hormones are made by the adrenal glands and help your body prepare for the "fight-or-flight" response. Rare tumors of the adrenal glands can create high levels of catecholamine hormones. When catecholamines are broken down by the body, another hormone called metanephrine is created. This test is used to measure the amount of metanephrines in your urine made over a 24-hour period.

What are the symptoms of too much catecholamine?

If your body makes too much catecholamine, symptoms may include high blood pressure, headaches, sweating, tremors, heart palpitations, trouble breathing, and paleness.

Who should get tested?

This test may be helpful if you:

  • Have spoken with your healthcare provider and have decided screening is right for you
  • Have signs or symptoms of a possible condition affecting your catecholamine production, and you and your healthcare provider have discussed screening

What will my test results tell me?

Test results may vary depending on your age, gender, and health history. Different labs have different ways of measuring catecholamine levels. Abnormal results may mean that you have an underlying condition, and you should discuss with your healthcare provider right away. Be sure to share your results with your healthcare provider so they can help you determine the next steps in your care.

Are there any risks involved in getting this test?

There is no risk involved in getting this test. This test is performed by collecting all of your urine for a 24-hour period. Your healthcare provider or the lab will give you specific instructions on how to collect and store your urine until you return it to the lab.

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